Pathology of histiocytoses of non-Langerhans cell type


Authors: L. Plank 1,2
Authors‘ workplace: Ústav patologickej anatómie a Konzultačné centrum bioptickej diagnostiky ochorení krvotvorby Jesseniovej lekárskej fakulty UK a UN Martin, Slovenská republika, prednosta prof. MU Dr. Lukáš Plank, CSc. 1;  Martinské bioptické centrum, s. r. o., Martin, Slovenská republika 2
Published in: Vnitř Lék 2010; 56(Supplementum 2): 39-63
Category: Langerhans cell histiocytosis and some other Hematology rare diseases

Overview

The paper offers a review on pathology of histiocytoses of non-Langerhans cell type, especially focused on neoplastic forms of the histiocytic disorders according to the WHO classification of tumours of hematopoietic and lymphoid tissues (2008). The review is based on lineage- specific histogenetical typing of histiocytic and dendritic cells distinguishing histiocytes (makrophages), dendritic cells of myeloid origin and dendritic cells of the stromal type (of mesenchymal origin). The tumours are classified as follows: histiocytic sarcoma, sarcoma of interdigitating, indetermined, dermal (intersticial) and plasmacytoid dendritic cellss and sarcomas (tumours) of follicular dendritic and fibroblastic reticular cells. Within each of the tumor categories, the histogenesis, clinical manifestation and prognosis is discussed and the histomorphology and phenotypic profile of the tumour is shortly described. Besides that also the relations of all these tumours to fibrohistiocytic tumours of the soft tissue category leading to classification conceptual problems are discussed.

Key words:
histiocyte –  dendritic cells –  non-Langerhans cell histiocytoses –  histiocytic sarcoma –  dendritic cell sarcomas and tumours –  fibrohistiocytic soft tissue tumours


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