The normalized smoothness index and parametric population RDH index of telmisartane in patients with newly diagnosed hypertension and metabolic syndrome

Authors: I. Řiháček 1;  P. Fráňa 1;  D. Schwarz 2;  M. Plachý 1;  M. Souček 1
Authors‘ workplace: II. interní klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta prof. MU Dr. Miroslav Souček, CSc. 2Institut bio­statistiky a analýz Lékařské fakulty MU Brno, přednosta doc. RNDr. Ladislav Dušek, Ph. D. 1
Published in: Vnitř Lék 2010; 56(6): 495-502
Category: Original Contributions


Ambulatory blood pressure monitoring provides an opportunity to evaluate 24- hour efficacy of once daily pre­parations.

Aims of the study:
To evaluate 24- hour efficacy of telmisartane in patients with newly diagnosed hypertension and metabolic syndrome using the parametric population RDH index and normalized smoothness index.

Patient sample and methodology:
Thirty newly diagnosed hypertonics with metabolic syndrome, sufficiently responding to blood pressure therapy with telmisartane, assessed using sphygmomanometer. Twenty six men, 4 women, mean age of 44 years, body mass index of 31.4 kg. m– 2, before and after 1 year of therapy. Blood pressure measured with sphygmomanometer and 24- hour ambulatory monitoring (SpaceLabs 90207) according to the criteria of the European Society of Hypertension. Hypertension was defined as sphygmomanometer- measured blood pressure values of more or equal to 130 and/ or 85 mm Hg. Fulfilment of at least 3 criteria of metabolic syndrome according to the definition by The Adult Treatment Panel III.

The population normalized smoothness index of telmisartane (± standard error of the mean) of 1.00 ± 0.11 for systolic pressure and 0.84 ± 0.10 for diastolic pressure. The parametric population RDH index of 24, 24, 0 for systolic pressure and 22, 15, 1 for diastolic pre­ssure.

Telmisartane at a mean dose of 60 mg once daily showed an adequate 24- hour efficacy in patients with newly dia­gnosed hypertension and metabolic syndrome responding to treatment, when blood pressure was measured using sphygmomano­meter and the effect expressed as the parametric population RDH index and normalized smoothness index based on systolic blood pressure value. We did not prove the full 24- hour efficacy when diastolic blood pressure was used to calculate both indexes.

Key words:
hypertension –  metabolic syndrome –  normalized smoothness index –  RDH index –  telmisartane


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