The FEVER (Felodipine EVEnt Reduction) trial; a randomised, double-blind, placebo-controlled trial in Chinese hypertensive patients

Authors: A. Mokráček 1;  J. Špatenka 2;  M. Šulda 1;  F. Toušek 1;  H. Pospíšilová 1;  M. Vambera 1;  M. Šetina 2;  L. Pešl 1
Authors‘ workplace: Kardiocentrum Nemocnice České Budějovice, ředitel MUDr. Ladislav Pešl 1;  Transplantační centrum a oddělení kardiovaskulární chirurgie Kardiovaskulárního centra FN Motol, Praha, přednosta prim. MUDr. Jaroslav Špatenka, CSc. 2
Published in: Vnitř Lék 2007; 53(1): 54-62
Category: Reviews


After 40 years of heart valve prostheses intensive development ideal valve substitute still does not exist. Aortic allograft represents one alternative which could be used for aortic and/or pulmonary valve replacement. This type of biological heart valve prosthesis is being currently discussed from the point of view of Tissue Banking, as well as from clinical aspects – e.g. surgical implantation technique and long term results. Live issue remains particularly the aortic allograft implantation into the aortic position. The authors discuss the aortic allograft role in the aortic valve infectious endocarditis treatment, which was widespread worldwide and accepted. Aortic allograft implantation is considered as a method of choice in that particular indication, especially in prosthetic aortic valve endocarditis and in left ventricle outlet tract destruction cases. The method is considered to be more technically demanding than routine heart valve surgery (heart valve replacement by means of mechanical or commercial biological prostheses), but literary and authors own experience in that particular group of patients looks encouraging. Aortic allografts permanent supply in our country is secured.

Key words:
infectious endocarditis - aortic valve - aortic allograft - aortic homograft


1. Gross RE, Hurvit ES, Bill AH et al. Prelimitary observations on the use of human arterial grafts. N Engl J Med 1948; 239: 587-595.

2. Lam CR, Aram HH, Munnell ER. An experimental study of aortic valve homografts. Surg Gyneacol Obstetr 1952; 94: 129-135.

3. Hubka M, Siska K, Brozman M et al. Replacement of mitral and tricuspid valves by mitral homograft. J Thorac Cardiovasc Surg 1966; 51: 195-204.

4. Hubka M, Holec V. Experimental replacement of the mitral valve by mitral homograft. Bratisl Lek Listy 1966; 46: 261-272.

5. Špatenka J, Honěk T, Kostelka M et al. Odběr srdce pro přípravu alotransplantátů srdečních chlopní. Rozhl Chir 1997; 76: 113-117.

6. Špatenka J, Kostelka M, Kobylka P et al. Příprava, skladování, transport a použití alotransplantátů srdečních chlopní. Rozhl Chir 1997; 76: 118-125.

7. Horstkotte D, Follath F, Gutschik E et al. Guidelines on prevention, diagnosis and treatment of infective endocarditis. ESC guidelines. Eur Heart J 2004; 25: 1-37.

8. Ross DN. Homograft replacement of the aortic valve. Lancet 1962; 487

9. Barrat-Boyes BG. Homograft aortic valve replacement in aortic incompetence and stenosis. Thorax 1964; 19: 131-150.

10. Kersten TE, Ross D. Aortic root replacement with aortic homograft. In: Emery RW, Arom KV. The aortic valve. Philadelphia, St. Louis, Baltimore, Boston, Chicago, London, Philadelphia, Sydney, Toronto: Mosby, Hanley & Belfus 1991; 245-261

11. Heimbecker RO, Baird RJ, Lajos RJ et al. Homograft replacement of the human valve. A preliminary report. Can Med Assoc J 1962; 86: 805-807.

12. Zákon č. 285/2002 Sb., tzv. Transplantační zákon.

13. Haydock D, Barrat-Boyes B, Macedo T et al. Aortic valve replacement for active infectious endocarditis. J Thorac and Cardiovasc Surg 1992; 103: 130-139.

14. Petrou M, Wong K, Albertucci M et al. Evaluation of unstented homografts for treatment of prostetic valve endocarditis. Circulation 1994; 90: 198-204.

15. Grinda JM, Mainardi JL, Berrebi A et al. Cryopreserved aortic allografts for treatment of active aortic endocarditis. Ann Thorac Surg 2005; 79: 767-771.

16. Sabik JF, Lytle BW, Blackstone EH et al. Aortic root replacement with cryopreserved allograft for prosthetic valve endocarditis. Ann Thorac Surg 2002; 74: 650-659.

17. Leyh RG, Knobloch K, Hagl CH et al. Replacement of the aortic root for acute prosthestic valve endocarditis: Prosthetic composite versus aortic allograft root repacement. J Thorac Cardiovasc Surg 2004; 127: 391-398.

18. Hagl CH, Galla JD, Lansman SL et al. Replacing the ascending aorta and aortic valve for acute prosthetic valve endocarditis: Is it using of prosthetic material contraindicated? Ann Thorac Surg 2002; 74: 1781-1785.

19. Blumberg I et al. Endocarditis-associated paravalvular abscesses. Chest 1995; 107: 898-903.

20. Lytle BW, Sabik JF, Blackstone EH et al. Reoperative cryopreserved root and ascending aorta replacement for acute aortic prosthetic valve endocarditis. Ann Thorac Surg 2002; 74: 1754-1757.

21. Delay D, Pellerin M, Carrier M et al. Immediate and long term results of valve replacement for native and prosthetic valve endocarditis. Ann Thorac Surg 2000; 70: 1219-1223.

22. Beneš J, Gregor P, Mokráček A. Infekční endokarditida. Doporučené postupy diagnostiky, léčby, dispenzarizace a profylaxe.

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