Systemic lupus erythematodes

Authors: J. Lukáč;  J. Rovenský;  O. Lukáčová;  D. Kozáková
Authors‘ workplace: Národný ústav reumatických chorôb, Piešťany, Slovenská republika, riaditeľ prof. MUDr. Jozef Rovenský, DrSc., FRCP
Published in: Vnitř Lék 2006; 52(7-8): 702-711
Category: 130th Internal Medicine Day - Rheumatology in clinical practice


Systemic lupus erythematodes (SLE) is chronic autoimmune disease, characteristic by production of autoantibodies against different autoantigens. Etiopathogenesis in not precise determinated, but genetic, immunologic, hormonal factors or influence of environment are assumed. It manifests by various symptoms and it can affect whichever organ or system in the body. Clinical manifestation are due chronic inflammation in the tissues, which is caused first of all by deposit of immunocomplex and by cytotoxic damage. At the last decades the mortality of patients with SLE is markly lower and their live is prolong. In spite of this diagnostic, to follow up and therapy of this disease is complicated and it requires the colaboration of more banches of medicine.

Key words:
systemic lupus erytheamtodes - diagnostic - clinical symptoms - course - therapy


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