Results of multi-centre monitoring of sibutramine treatment in obese diabetic patients in Czech Republic

Authors: A. Šmahelová
Authors‘ workplace: Klinika gerontologická a metabolická Lékařské fakulty UK a FN, Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc.
Published in: Vnitř Lék 2005; 51(6): 676-680
Category: Original Contributions


Sibutramine is a very effective antiobesitic drug in the present. It has weight reducing, global metabolic and antidiabetic effects. To verify and to get the experiences with practical use of sibutramin in Type 2 diabetics in the Czech Republic was the purpose of the clinical observation MERIDIOS I.

Patients and methods:
499 diabetics (average age 52.4 ± 9,5 years) were included, to the statistical evaluation after 3 months of the therapy Wilcoxon rank sum test was used. 308 (61,7%) diabetics took oral antidiabetic agents. 424 (83%) diabetics used antihypertensive drugs, 384 (75%) hypolipidemic agents. 275 (55.1%) diabetics took sibutramine in the dose 10 mg once a day, 224 (44.9%) diabetics in the dose 15 mg once a day.

The average weight loss was 6.1 kg (p < 0.001). Waist circumference diminished about 4.7 cm (p < 0.001), glycosylated hemoglobin about 0.75% (p < 0.001), systolic blood pressure about 5.2 mm Hg (p < 0.001), diastolic blood pressure about 3.1 mm Hg (p < 0.001) in average. The daily dosage of oral antidiabetic agents diminished in 33.1% of all included diabetics. Any serious adverse events of sibutramine were recorded.

Significant weight loss, diminished waist circumference and blood pressure, improvement of diabetes compensation and lower daily dose of oral hypoglycemic agents were observed in obese Type 2 diabetics after 3 months therapy with sibutramine in the dose 10 or 15 mg per day.

Key words:
diabetes mellitus type 2 – sibutramin – obesity


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Diabetology Endocrinology Internal medicine

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