Prolonged administration of low-molecular heparins in the prophylaxis of postoperative thrombosis


Authors: M. Čepelák
Authors‘ workplace: I. interní klinika Lékařské fakulty UK a FN Plzeň, přednosta prof. MUDr. Karel Opatrný jr., DrSc.
Published in: Vnitř Lék 2005; 51(5): 555-559
Category: Reviews

Overview

Low-molecular-heparins have become a standard medication of venous thrombosis prevention in orthopaedic and general surgery. Reasons for extended prophylaxis with low–molecular heparins after hospital discharge are best evident in patients with total hip replacement. In this patient group a high incidence of thromboembolic complications in the late period after surgery has been ascertained and the origin of new asymptomatic thrombosis cases has been documented by phlebography and duplex sonography. A prolonged treatment with low–molecular heparins leads to a significant lowering of the frequency of manifest as well as asymptomatic thrombosis and finds application in other indications of thrombosis prophylaxis as well.

Key words:
low-molecular heparins – preventionpostoperative thrombosis – total hip replacement – thromboembolic complications


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