#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Comments on controversies on the importance of vitamin C in oncology


Authors: P. Klener
Authors‘ workplace: Přednosta: prof. MUDr. Marek Trněný, CSc. ÚHKT, Praha ;  Ředitel: prof. MUDr. Petr Cetkovský, PhD. ;  I. interní klinika 1. LF UK a VFN, Praha
Published in: Prakt. Lék. 2015; 95(5): 196-198
Category: Reviews

Overview

Intravenous administration of high doses of vitamin C may reduce toxicity of chemotherapy. However, there is no high-quality evidence to suggest that this treatment in cancer patients enhances the antitumor effects. Placebo controlled trials are needed. Therapy with high dosage of vitamin C is non-toxic and may be used as complementary treatment when conventional anticancer therapy has to be terminated..

Keywords:
vitamin C – high intravenous dosage – cancer


Sources

1. Stone I. The healing factor: vitamin C against disease. New York: Grosset and Dumlap 1974.

2. Pohanka M, Pejchal J, Snopková S, et al. Ascorbic acid: On old player with a broad impact on body physiology including oxidative stress supression and immunomodulation: A review. Mini Rev Med Chem 2012; 1: 35–43.

3. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am J Clin Nutr 1991; 54: 1119–1122.

4. Gorton HC, Jarvis K. The effectivenes of vitamin C on preventing the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther 1999; 8: 530–532.

5. Chambial S, Dwivedi S, Shukla KK, et al. Vitamin C in disease prevention and cure: an overwiev. Indian J Clin Biochem 2013; 4: 314–328.

6. Parrow NL, Leshin JA, Levine M. Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antiox Redox Signal 2013; 19: 2141–2156.

7. Verrax J, Calderon PB. Pharmacologic concentration of ascorbate are achieved by parenteral administration and exhibit antitumor effect. Free Radic Biol Med 2009; 47: 32–40.

8. Gonzales MJ, Miranda-Massari JR. New insight on vitamin C and cancer. Heildeberg: Springer 2014.

9. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1978; 75: 4538–4542.

10. Creagan ET, Moertel CG, O´Fallon JR, et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979; 301: 687–690.

11. Kostiuk P, Kotlářová L, Procházka Z, Slíva J. Využití kyseliny askorbové v onkologii. Praha: Edukafarm 2013.

12. Yiang GT, Chou PL, Hung YT, et al. Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells. Oncol Rep 2014; 3: 1085–1063.

13. Huang XC, Maimaiti XY, Huabg CW, et al. Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a system biology analysis. Eur Rev Med Pharmacol Sci 2014; 18: 3877–3788.

14. Cullen JJ, Kubecová J, Marjirský M., a kol. Využití intravenózního vitaminu C u onkologického pacienta. Onkologie 2013; 7: 196–200.

15. Ma Y, Chapman J, Levine M, et al. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med 2014; 5: 222–228.

16. Fritz H. Intravenous vitamin C and cancer: A systematic review. Integr Cancer Ther 2014; 13: 280–300.

17. Jacobs C, Hutton B, Ng T, et al. Is there a role for oral intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist 2015; 20: 210–223.

18. Hoffer LJ, Robitaille L, Zakarian R, et al. High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: A phase I-II clinical trial. PLosOne 2015; 10(4): e0120228.

19. Barnes LA. Safety consideration with high ascorbic acid dosage. Ann NY Acad Sci 1975; 258: 253–258.

20. Mikirova N, Csciari J, Riordan N, et al. Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients. J Transpl Med 2013; 11: 191–200.

21. Carr AC, Vissers MC, Cook JS. The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Front Oncol 2014; 4: 283–285.

22. National Cancer Institute. High-dose vitamin C-for health professionals (PDQ®) [online]. Dostupné z: http://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq.

Labels
General practitioner for children and adolescents General practitioner for adults
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#