Faecal calprotectin


Authors: D. Kamenář;  J. Špičák
Authors‘ workplace: Institut klinické a experimentální medicíny, Praha, Klinika hepatogastroenterologie, Přednosta: prof. MUDr. Julius Špičák, CSc.
Published in: Prakt. Lék. 2011; 91(11): 665-669
Category: Diagnostis

Overview

Calprotectin is a calcium-binding protein contained in neutrophils. Inflammatory damage of the intestinal mucosa causes an influx of neutrophils into the intestinal lumen, after which increased calprotectin levels can be measured in stools. Calprotectin in faeces is a good marker of inflammation and disease activity in inflammatory bowel disease, and is suitable for assessment of disease course, monitoring of treatment effect and probably predicting relapses. Normalization of faecal calprotectin seems to be a strong indicator of healing of the intestinal mucosa. Calprotectin is of some differential diagnostic value in patients with irritable bowel syndrome and it can make indications to colonoscopy more accurate in these patients.

Key words:
calprotectin, Crohn disease, inflammatory bowel disease, irritable bowel disease, ulcerative colitis.


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