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Baroreflex sensitivity and risk stratification of hypertensives


Authors: D. Čelovská 1;  J. Staško 2;  J. Gonsorčík 3;  A. Dukát 1
Authors‘ workplace: II. interná klinika LF UK a FNsP Bratislava, Prednosta: prof. MUDr. Andrej Dukát, CSc., FESC, 2Klinika kardiológie FNsP J. A. Reimana Prešov, Prednosta: doc. MUDr. Alexander Kiško, CSc., 3Klinika kardiológie LF UPJŠ a VÚSCH Košice, Prednosta: MUDr. Branis 1
Published in: Prakt. Lék. 2010; 90(7): 418-422
Category: Of different specialties

Overview

Examination of baroreflex sensitivity (BRS) is a non-invasive marker of autonomic dysfunction. Reduced BRS is associated with a shift in autonomic balance towards sympathetic dominance, which leads to initiation of arterial hypertension, disease progression as well as complications related to global cardio-vascular risk in the long term. The aim of the study was to evaluate the clinical significance of baroreflex sensitivity for risk stratification in hypertensive subjects. We found out that essential hypertension is associated with decreased BRS, and that grade of hypertension is inversely related to BRS values. BRS is a clinically applicable, non-invasive method for assessing early dysfunction of autonomic nervous system, which seems to be an additive emerging marker of cardiovascular risk stratification in hypertensive patients.

Key words:
baroreflex sensitivity, autonomic nervous system, arterial hypertension, stroke, myocardial infarction.


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