Comparison of dietary habits of patients with colorectal neoplasias and their first-degree relatives


Authors: I. Mikoviny Kajzrlíková 1;  P. Vítek 1,2;  J. Chalupa 1;  P. Dítě 2
Authors‘ workplace: Beskydské Gastrocentrum, Interní oddělení, Nemocnice ve Frýdku-Místku, p. o. 1;  Katedra interních oborů, Lékařská fakulta, Ostravská univerzita v Ostravě 2
Published in: Gastroent Hepatol 2014; 68(3): 202-206
Category: Digestive Endoscopy: Original Article

Overview

First-degree relatives of patients with colorectal neoplasias have a higher risk of colorectal cancer than the general population. Colorectal cancer has hereditary as well as nonhereditary risks. The aim of our study was to compare the dietary habits between colorectal neoplasia patients, their first-degree relatives, and a reference group of individuals without medical record and without the finding of neoplastic lesions.

Methods:
From July 2008 to April 2011, we collected epidemiological data relevant to colorectal cancer from patients with colorectal neoplasias, their first-degree relatives, and also from the control group. The ­dietary habits of all groups were compared. Chi-square test and Fisher's exact test were used to assess the association between the two dichotomous categorical variables.

Results:
The study groups consisted of 242 patients with colorectal neoplasias (143 men, 99 women) and 160 first-degree relatives (66 men, 94 women). Fifty-five of the first-degree relatives were found to have a neoplastic lesion upon colonoscopy, while the remaining 105 were without neoplasia. The control group consisted of 123 individuals with a negative family history for neoplastic lesions (66 men, 57 women). No significant differences were observed in the dietary habits between the groups of patients, controls and first-degree relatives with/without neoplastic lesions. Nevertheless, statistically significant sex-related differences were observed in all groups, in which women had healthier dietary habits than men.

Conclusions:
There were no significant differences in the dietary habits between the groups, but in all groups examined, women had ­healthier dietary habits than men. We propose that media campaigns should be targeted at the male population, due to the need to improve their lifestyle.

Key words:
colorectal neoplasias – dietary habits – risk factors – family – mass screening

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
30. 4. 2014

Accepted:
27. 5. 2014


Sources

1. Ústav zdravotnických informací a statistiky ČR. Novotvary 2008. [online]. Dostupné z: http://www.uzis.cz/katalog/zdravotnicka-­-statistika/novotvary.

2. Manser CN, Bachmann LM, Brunner J et al. Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study. Gastrointest Endosc 2012; 76(1): ­110–117. doi: 10.1016/j.gie.2012.02.040.

3. Zavoral M, Suchanek S, Zavada F et al. Colorectal cancer screening in Europe. World J Gastroenterol 2009; 15(47): 5907–5915.

4. Zavoral M, Suchánek Š, Májek O et al. Národní program screeningu kolorektálního karcinomu v České republice – minulost, přítomnost a budoucnost. Gastroent Hepatol 2012; 66(5): 345–349.

5. Winawer SJ, Schottenfeld D, Flehinger BJ. Colorectal cancer screening. J Natl Cancer Inst 1991; 83(4): 243–253.

6. Johns LE, Houlston RS. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001; 96(10): 2992–3003.

7. Neklason DW, Thorpe BL, Ferrandez A et al. Colonic adenoma risk in familial colorectal cancer – a study of six extended kindreds. Am J Gastroenterol 2008; 103(10): 2577–2584. doi: 10.1111/j.1572-0241.2008.02019.x.

8. Wark PA, Wu K, van't Veer P et al. Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity? Int J Cancer 2009; 125(2): ­413–420. doi: 10.1002/ijc.24288.

9. Cottet V, Pariente A, Nalet B et al. Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors. Gastroenterology 2007; 133(4): 1086–1092.

10. Brenner H, Altenhofen L, Hoffmeister M. Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis. Ann Intern Med 2010; 152(11): ­697–703. doi: 10.7326/0003-4819-152-11-201006010-00002.

11. Norat T, Bingham S, Ferrari P et al. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst 2005; 97(12): 906–916.

12. Botteri E, Iodice S, Bagnardi V et al. Smoking and colorectal cancer: a meta-analysis. JAMA 2008; 300(23): 2765–2778. doi: 10.1001/jama.2008.839.

13. Cho E, Smith-Warner SA, Ritz J et al. Alcohol intake and colorectal cancer: a po­oled analysis of 8 cohort studies. Ann Intern Med 2004; 140(8): 603–613.

14. Renehan AG, Tyson M, Egger M et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008; 371(9612): 569–578. doi: 10.1016//S0140-6736(08)60269-X.

15. Chan AO, Jim MH, Lam KF et al. Prevalence of colorectal neoplasm among pa­tients with newly diagnosed coronary artery disease. JAMA 2007; 298(12): 1412–1419.

16. Ma J, Pollak MN, Giovannucci E et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-bind­ing protein-3. J Natl Cancer Inst 1999; 91(7): 620–625.

17. Delhougne B, Deneux C, Abs R et al. The prevalence of colonic polyps in acromegaly: a colonoscopic and pathological study in 103 patients. J Clin Endocrinol Metab 1995; 80(11): 3223–3226.

18. Rowland IR. The role of the gastrointestinal microbiota in colorectal cancer. Curr Pharm Des 2009; 15(13): 1524–1527.

19. Bures J, Horák V, Fixa B et al. Colicinogeny in colorectal cancer. Neoplasma 1986; 33(2): 233–237.

20. Davis CD, Milner JA. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 2009; 20(10): 743–752. doi: 10.1016/j.jnutbio.2009.06.001.

21. Jasperson KW, Tuohy TM, Neklason DW et al. Hereditary and familial colon cancer. Gastroenterology 2010; 138(6): ­2044–2058. doi: 10.1053/j.gastro.2010.01.054.

22. Houlston RS, Tomlinson IP. Polymor­phisms and colorectal tumor risk. Gastroenterology 2001; 121(2): 282–301.

23. Tenesa A, Dunlop MG. New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet 2009; 10(6): 353–358. doi: 10.1038/nrg2574.

24. Grady WM. Genomic instability and colon cancer. Cancer Metastasis Rev 2004; 23(1–2): 11–27.

25. Weisenberger DJ, Siegmund KD, Campan M et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38(7): 787–793.

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Paediatric gastroenterology Gastroenterology and hepatology Surgery

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