Phylogenetic Analysis and Genotyping of A/H3N2 Influenza Viruses Isolated from Patients Hospitalised with Influenza-Like Illness Symptoms in the Na Bulovce Hospital in the Season 2011/2012

Czech version

Authors: Nagy Alexander ¹; Jiřincová Helena ¹; Havlíčková Martina ¹; Džupová Olga ^2,4; Herrmannová Kristýna ^3,4; Trojánek Milan ^3,4; Marešová Vilma ^3,4; Nováková Ludmila ¹; Kynčl Jan ¹
Authors‘ workplace: Státní zdravotní ústav, Centrum epidemiologie a mikrobiologie, Praha ¹; 3. lékařská fakulta, Univerzita Karlova v Praze ²; 2. lékařská fakulta, Univerzita Karlova v Praze ³; Klinika infekčních nemocí, Nemocnice Na Bulovce, Praha ⁴
Published in: Epidemiol. Mikrobiol. Imunol. 62, 2013, č. 1, s. 4-8

Overview

Influenza A virus is an important cause of acute respiratory infections (ARI). Clinical manifestations of ARI vary from mild or moderate to life-threatening conditions requiring intensive care. Given the segmented genome, a large natural reservoir of other influenza virus subtypes, and antibody selection pressure in the population, the virus is variable and genetically unstable. The phylogenetic analysis and genotyping of A/H3N2 influenza viruses isolated from patients hospitalised with influenza-like illness symptoms in the Na Bulovce Hospital in the season 2011/2012 support the assumption that the pathogenicity is a polygenic trait modifiable by the host health status and seems not to be unambiguously associated with any specific mutations.

Keywords:
influenza A virus, phylogenetic analysis – genotyping – hospitalization – clinical symptoms

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Labels

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Article was published in

Epidemiology, Microbiology, Immunology

2013 Issue 1