Phylogenetic Analysis and Genotyping of A/H3N2 Influenza Viruses Isolated from Patients Hospitalised with Influenza-Like Illness Symptoms in the Na Bulovce Hospital in the Season 2011/2012


Authors: Nagy Alexander 1;  Jiřincová Helena 1;  Havlíčková Martina 1;  Džupová Olga 2,4;  Herrmannová Kristýna 3,4;  Trojánek Milan 3,4;  Marešová Vilma 3,4;  Nováková Ludmila 1;  Kynčl Jan 1
Authors‘ workplace: Státní zdravotní ústav, Centrum epidemiologie a mikrobiologie, Praha 1;  3. lékařská fakulta, Univerzita Karlova v Praze 2;  2. lékařská fakulta, Univerzita Karlova v Praze 3;  Klinika infekčních nemocí, Nemocnice Na Bulovce, Praha 4
Published in: Epidemiol. Mikrobiol. Imunol. 62, 2013, č. 1, s. 4-8

Overview

Influenza A virus is an important cause of acute respiratory infections (ARI). Clinical manifestations of ARI vary from mild or moderate to life-threatening conditions requiring intensive care. Given the segmented genome, a large natural reservoir of other influenza virus subtypes, and antibody selection pressure in the population, the virus is variable and genetically unstable. The phylogenetic analysis and genotyping of A/H3N2 influenza viruses isolated from patients hospitalised with influenza-like illness symptoms in the Na Bulovce Hospital in the season 2011/2012 support the assumption that the pathogenicity is a polygenic trait modifiable by the host health status and seems not to be unambiguously associated with any specific mutations.

Keywords:
influenza A virus, phylogenetic analysis – genotyping – hospitalization – clinical symptoms


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Labels
Hygiene and epidemiology Medical virology Clinical microbiology
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