The Gastric Emptying of a Solid Meal in Cystic Fibrosis Patients Assessed by the 13C-OctanoicAcid Breath Test

Authors: D. Neumann;  O. Pozler;  V. Voříšek 1;  H. Vaníček;  J. Bureš 2
Authors‘ workplace: Dětská klinika, Fakultní nemocnice, Hradec Králové přednostka doc. MUDr. E. Pařízková, CSc. Ústav klinické biochemie a diagnostiky, Fakultní nemocnice, Hradec Králové1 přednosta prof. MUDr. V. Palička, CSc. II. interní klinika, Fakultní nemocnice, Hradec
Published in: Čes-slov Pediat 2003; (6): 374-377.


The 13C-octanoic acid breath test (13C-OABT) is the most precise breath test for the assessment of gastricemptying. The presented study concentrates on gastric emptying of a solid meal in CF patients.Method: The solid testmeal (cake) was administered with 65 microlitres of 13C-octanoic acid. Patients collectedbreath samples throughout a 4-hour period. The air samples were examined by mass spectrometry to obtain deltavalues, which were transformed to the elimination pattern of 13C. The gastric emptying half times (T1/2GE) werecounted by MOMENT 4 programme, modelling elimination as incomplete gamma function. The incompletegamma parameters estimation was done by themomentmethod. The T1/2GEs were compared with reference dataobtained by Van Den Driessche (25). The 13C-OABT was performed in 20 patients, median age 13.5 years.Results: 13C-OABT were analyzed in 16 patients. In 69% of them T1/2GEs were in the reference range, in 25%below and in 6% prolonged. The difference in delta values remained in CF 13C-OABT low.Conclusion: The gastric emptying rate in CF patients does not differ in principle from the healthy population.

Key words:
gastric emptying, 13C-OABT, cystic fibrosis

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