Impaired Glucose Tolerance and Diabetes in Patients with Cystic Fibrosis

Authors: S. Koloušková;  D. Zemková;  J. Bartošová;  Z. Šumník;  V. Vávrová
Authors‘ workplace: II. dětská klinika 2. LF UK a FN Motol, Prahapřednosta doc. MUDr. J. Vavřinec, DrSc.
Published in: Čes-slov Pediat 2003; (5): 270-273.


Impaired glucose tolerance and diabetes mellitus (CFRD - cystic fibrosis related diabetes) are a frequentcomplication in patients with cystic fibrosis. Within the framework of CFRD screening the authors examined in122 patients above the age of 10 years without clinical symptoms of diabetes mellitus the oral glucose tolerance test(oGTT). In subjects with a pathological oGTT subsequently the intravenous glucose tolerance test was made toassess stimulated insulin secretion (FPIR; sum of insulin levels during the 1st and 3rd minute after an i.v. glucosebolus). CFRD was diagnosed in 19/122 patients (15.6%), impaired glucose tolerance in 18/122 (14.8%). A total of37/122 (30.3%) patients with impaired glucose tolerance or CFRD were diagnosed. Marked insulinopenia (FPIR< 48 mIU/l) was found in a total of 29/122 patients (23.8%), incl. 10/18 with impaired glucose tolerance. The findingof marked insulinopenia makes it possible also in patients with impaired glucose tolerance to select rationallyindividual therapeutic procedures.

Key words:
cystic fibrosis, diabetes mellitus, CFRD, impaired glucose tolerance, FPIR

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Neonatology Paediatrics General practitioner for children and adolescents

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Czech-Slovak Pediatrics

2003 Issue 5

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