Primary cilia of connective tissue cells

Authors: J. Dvořák 1;  Z. Dvořák 2;  V. Sitorová 3;  Nikolov Dh 3;  J. Mokrý 4;  I. Richter 5,6;  S. Filip 1;  A. Ryška 3;  J. Petera 1
Authors‘ workplace: Klinika onkologie a radioterapie LFUK a FN Hradec Králové, 2ARTHROMED, s. r. o., Pardubice, 3Fingerlandův ústav patologie LFUK a FN Hradec Králové, 4Ústav histologie a embryologie LFUK Hradec Králové, 5Oddělení klinické onkologie, Krajská nemocnice Libere 1
Published in: Čes. Revmatol., 20, 2012, No. 4, p. 170-174.
Category: Overview Reports


The primary cilium is a sensory, solitary, non-motile microtubule-based structure protruding in the quiescent phase of the cell cycle from the surface of the majority of human cells, including mesenchymal stem cells, osteoblasts, osteocytes, chondroblasts, chondrocytes, fibroblasts, fibrocytes, chondrocytes of osteoarthritic cartillage, tumor cells of benign and malignant tumors of connective tissue, including enchondroma, osteochondroma, osteosarcoma, chondrosarcoma and Ewing bone sarcoma. Primary cilium is formed from the mother centriole. The aim of this paper is to provide a review of the current knowledge on the primary cilia in connective tissue cells.

Key words:
primary cilia, epiphyseal plate, bone tumors, osteoarthritis


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