Abatacept and its use for the treatment of rheumatoid arthritis in the Czech Republic – data from the ATTRA registry


Authors: P. Horák 1;  M. Skácelová 1;  K. Hejduk 2;  K. Pavelka 3
Authors‘ workplace: III. interní klinika – nefrologická, revmatologická, endokrinologická, Lékařská fakulta Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc, 2Institut biostatistiky a analýz, Masarykova univerzita v Brně, 3Revmatologický ústav Praha, 1. Lékařská 1
Published in: Čes. Revmatol., 20, 2012, No. 4, p. 163-169.
Category: Original Papers

Overview

The Czech national registry ATTRA collects the data of patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and juvenile idiopatic arthritis treated with biological drugs. ATTRA is a prospective centralized computerized registry of patients and collects the data on efficacy, safety and quality of life. Currently, abatacept has the position of a second line agent for RA which can be prescribed after a failure of at least one TNFα inhibitor. A total of 162 patients with RA treated by abatacept were included into the current analysis with the mean age of 51.0±12.2 (median 53.1, 19-74 years). The mean disease duration was 14±9.1, median 11.3 years (0-41). One hundred and thirty patients (80.2%) were females. The mean DAS28 at week 0 was 5.9±1.1, at week 16 4.1±1.4, at week 24 3.8±1.2, at week 36 3.6±1.3 and at week 52 3.5±1.2. DAS28 remission was achieved at week 0 in 0.6%, at week 16 in 15.8%, at week 24 in 10%, at week 36 20.9% and at week 52 20.8%. Patients with DAS28 <2.6 (remission) at week 16 had the DAS28 <2.6 also at the week 52 in 58.3% of cases. Patients with DAS28 >5.1 (high disease activity) at the week 16 had DAS28 >5.1 at the week 52 in 41.7%. One year on treatment survival was 82%. Altogether 50 non-serious adverse events (AE) were reported in 36 patients (22%) and 11 serious AE in 10 patients (6%) with most common AE being infections (31) and skin rashes (5) and just one non-serious allergic reaction was reported. Data from registry confirms a good overall efficacy and safety and a very good on-drug survival of abatacept.

Key words:
rheumatoid arthritis, registries, abatacept


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Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
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