HLA-Cw*0602 is a predisposing allele to develop psoriatic arthritis


Authors: M. Fojtíková 1;  J. Štolfa 1;  L. Šedová 1;  J. Gatterová 1;  J. Lippert 3;  M. Černá 2
Authors‘ workplace: Revmatologický ústav, Praha, 2Institut biochemie, buněčné a molekulární biologie, 3. LF UK Praha, 3Dermatovenerologická klinika FNKV a 3. LF UK, Praha 1
Published in: Čes. Revmatol., 17, 2009, No. 2, p. 68-73.
Category: Original Papers

Overview

Introduction:
Psoriatic arthritis (PsA) is a member of the group of spondylarthropathies. It is defined as an arthritis, generally seronegative, which accompanies psoriasis. Etiopathogenesis of this disease is not entirely clear; both environmental factors and genetic predisposition are considred. The most significant genetic predisposition for the development of PsA was identified within the short arm of the chromosome 6 in the area of major histocompatibility complex (PSORS 1).

Aim of the study:
To identify the HLA-Cw alleles of the HLA class I gene associated with a risk of development of PsA, a type of psoriasis, and development of radiographic erosions.

Methods:
A total of 102 patients with PsA were examined; they were divided according to a) occurrence of erosions in radiographic examination (erosive / nonerosive), and b) age at the onset of psoriasis manifestation (type I psoriasis with the onset of cutaneous manifestations before the 40th year of age / type II psoriasis at the age exceeding 40 years). PCR-SSP method was used for genotyping. Statistical analysis was performed using χ2 and Fischer exact test; Bonferroni test was used for multiple comparison.

Results:
1. We have found a significantly increased frequency of HLA-Cw*06 alleles in the group of patients with PsA (35.3%) in comparison with healthy Czech population (16.2%), Pc <0.05 (OR 2.43, CI 95%: 1.32-4.76). The most frequent HLA-Cw*06 allele found in both groups was HLA-Cw*0602 allele, which is associated with development of PsA in patients with psoriasis (frequency 22.5%), compared to healthy individuals (frequency 10.1%), Pc <0.05 (OR 2.74, CI 95%: 1.20-6.25). 2. HLA-Cw*0602 allele is statistically significantly associated with development of PsA in patients with type I psoriasis (allele frequency is 28.0%), compared to healthy individuals: Pc <0.05; OR 3.12; CI 95% 1.38-7.14. The frequency of this allele was comparable in the group of PsA associated with type II psoriasis and in the group of healthy individuals. We have found no significant difference in the distribution of HLA-Cw alleles depending on occurrence of erosions in radiographic examination.

Conclusion:
HLA-Cw*0602 increases the likelihood of development of PsA, mainly in patients with the onset of cutaneous manifestations before the 40th year of age. This allele is not associated with development of radiographic erosions. We have found no statistically significant differences in the distribution of other HLA-Cw alleles in patients with psoriatic arthritis.

Key words:
HLA-Cw, psoriatic arthritis, genetic predisposition


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Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
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