Specific and associated autoantibodies in polymyositis and dermatomyositis

Authors: M. Modrá;  J. Vencovský
Authors‘ workplace: Revmatologický ústav, Praha
Published in: Čes. Revmatol., 16, 2008, No. 4, p. 169-176.
Category: Overview Reports


Polymyositis and dermatomyositis belong to idiopathic inflammatory myopathies. They are characterized by many clinical manifestations and the autoantibody profile of a patient can be helpful in determination of the particular diagnosis. The autoantibodies in polymyositis and dermatomyositis are divided into the following groups: myositis specific, myositis associated and tissue specific antibodies. Specific antibodies, which have a high predictive value in determining the diagnosis, are the most important ones. A basic review of autoantibodies found in myositis is given in this article. Recently discovered autoantibodies, such as anti-CADM-140, anti-p140/155 and anti-SAE, are mentioned as well.

Key words:
polymyositis, dermatomyositis, autoantibodies


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