Congenital heart block caused by maternal autoantibodies anti-SSA/Ro and anti-SSB/La


Authors: M. Podrazil;  J. Bartůňková;  A. Šedivá
Authors‘ workplace: Ústav imunologie UK 2. LF a FN Motol, Praha
Published in: Čes. Revmatol., 16, 2008, No. 4, p. 163-168.
Category: Overview Reports

Overview

Neonatal lupus syndrome represents a model of passively acquired autoimmunity caused by specific maternal autoantibodies anti-SSA/Ro a anti-SSB/La, which cross the placenta and are associated with the development of congenital heart block in the fetus and/or a transient rash or various liver and blood cell abnormalites in the newborn. Complete form of congenital heart block is a permanent condition that entails significant morbidity, with nearly all affected infants requiring pacemakers. Perinatal mortality may aprroach up to 20 %. An intensive search is therefore ongoing for the specific etiopathophysiology and for diagnostic markers to approach and treat this disease.

Key words:
congenital heart block, neonatal lupus syndrome, autoantibodies anti-SSA/Ro a anti-SSB/La


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Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
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