Authors: C. Dostál; V. Tesař 1; I. Rychlík 2; J. Žabka 1; J. Vencovský; J. Bartůňková 1; A. Stejskalová 2; D. Tegzová Authors‘ workplace: Revmatologický ústav, Praha, ředitel doc. MUDr. K. Pavelka, CSc. 1 Nefrologické odd. I. interní kliniky 1. LF UK, Praha, přednosta prof. MUDr. P. Klener, DrSc. 2 Hlavův patologicko-anatomický ústav 1. LF UK, Praha, přednosta prof. MUDr. P. Miřejovský, DrS Published in: Čes. Revmatol., , 1998, No. 4, p. 147-155. Category:
The objective of the investigation was to assess the effect of one-year treatment with small doses of cyclosporin A (CyA) on the disease activity and organ affection, in particular of the kidneys in systemic lupus erythematosus (SLE). The patients included in this trial suffered from active disease defined by the index of organ activity SLEDAI. Organ affection implied in all patients the presence of active lupus nephritis, classified by renal biopsy according to WHO in some neuropsychic manifestations, polyarthritis, serositis and dermal vasculitis. The trial comprised a total of eleven patients with SLE. After 12 months of treatment with CyA the mean activity score of SLEDAI declined significantly from 24.36 to 5.55 (p
Key words: systemic lupus erythematosus, lupus nephritis, cyclosporin A
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