Molecular mechanisms leading to fibrosis in endometriosis

Czech version

Authors: Zdeňka Lisá ¹; Radoslav Janoštiak ²; Kristýna Hlinecká ¹; Adéla Richtárová ¹; David Kužel ¹; Michal Mára ¹; Michael Fanta ¹
Authors‘ workplace: Centrum pro dia gnostiku a léčbu endometriózy a minimálně invazivní chirurgie, Klinika gynekologie, porodnictví a neonatologie, 1. LF UK a VFN v Praze ¹; Laboratoř molekulární onkologie, BIOCEV, 1. LF UK, Praha ²
Published in: Ceska Gynekol 2025; 90(2): 167-172
Category:
doi: https://doi.org/10.48095/cccg2025167

Overview

Endometriosis is a complex chronic disorder with a high prevalence among women of reproductive age, significantly affecting both their quality of life and ability to conceive. In clinical settings, there is an increasing incidence of advanced disease stages, particularly deep infiltrating endometriosis, which not only produces severe clinical symptoms, but also results in organ involvement. This article aims to synthesize current insights into the pathological mechanisms underlying fibrotic remodelling, which is associated with the most severe manifestations of the disease. Furthermore, it provides the theoretical framework for an ongoing research project aimed at identifying molecular biomarkers implicated in the most advanced forms of endometriosis, with the potential to enhance prediction of disease progression.

Keywords:

Endometriosis – deep infiltrating endometriosis – biomarkers of fibrosis – cellular and molecular mechanism of fibrosis – epithelial-to-mesenchymal transition

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ORCID autorů

Z. Lisá 0000-0003-4961-7063

R. Janoštiak 0000-0002-6602-9389

K. Hlinecká 0000-0002-8452-8333

A. Richtárová 0000-0001-7635-4858

D. Kužel 0000-0003-4262-9766

M. Mára 0000-0001-8222-3141

M. Fanta 0000-0002-8759-2533

Doručeno/Submitted: 6. 11. 2024

Přijato/Accepted: 19. 11. 2024

doc. MUDr. Michael Fanta, Ph.D.

Klinika gynekologie,