Agressive small cell carcinoma of the ovary, hypercalcemic type, surgery and oncological treatment: case report


Authors: M. Kapoun 1;  J. Bouda 1;  J. Presl 1;  P. Vlasák 1;  R. Slunečko 2
Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Novotný, CSc. 1;  Šiklův ústav patologie LF UK a FN, Plzeň, přednosta prof. MUDr. M. Michal, Ph. D. 2
Published in: Čes. Gynek.2015, 80, č. 3 s. 218-221

Overview

Small cell carcinoma of the ovary (SCCOHT) is a rare tumor typically affecting young women. It is a highly malignant tumor accompanied with poor prognosis, early relapse and low survival rates. The most significant prognostic factor is stage of the disease. Due to above mentioned factors there are no guidelines for therapy of this rare tumor.

We present a case of 22-years-old patient initially treated with antibiotics under diagnosis of pelvic inflammatory disease. Due to persistent mass at left adnexa, she was indicated for diagnostic laparoscopy, converted to laparotomy and left adnexectomy with frozen section revealing unspecified malignant tumor of left ovary. A conservative operation was performed and, after diagnosis of SCCOHT was established, the patient was indicated for adjuvant chemotherapy.

Keywords:
SCCOHT – conservative surgery – chemotherapy


Sources

1. Cohen, JG., Chan, JK., Kapp, DS. The management of small-cell carcinomas of the gynecologic tract. Curr Opin Oncology, 2012, 24 (5), p. 572–579.

2. Dickersin, GR., Kline, IW., Scully, RE. Small cell carcinoma of the ovary with hypercalcemia: a report of 11 cases. Cancer, 1982, 49, p. 188–197.

3. Eichhorn, JH., Young, RH., Scully, RE. Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases. Am J Surg Pathol, 1992, 16, p. 926–938.

4. Harrison, ML., Hoskins, P., du Bois, A., et al. Small cell of the ovary, hypercalcemic type – analysis of combined experience and recommendation for management. A GCIG study. Gynecol Oncol, 2006, 100, p. 233–238.

5. McDonald, JM., Karabakhtsian, RG., Pierce, H., et al. Small cell carcinoma of the ovary of hypercalcemic type: a case report. J Pediatr Surg, 2012, 47, p. 588–592.

6. Pautier, P., Ribrag, V., Duvillard, P., et al. Results of a prospective dose – intense regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type. Ann Oncol, 2007, 18, p. 1985–1989.

7. Powell, JL., McAfee, RD., McCoy, RC., Shiro, BS. Uterine and ovary conservation in advanced small cell carcinoma of the ovary. Obstet Gynecol, 1998, 91, p. 846–848.

8. Reed, NS., Pautier, P., Lundqvist, EA., et al. Gynecologic Cancer Intergroup (GCIG) consensus review for ovain small cell cancers. Int J Gynecol Cancer, 2014, 24, p. 30–33.

9. Reed, WC. Small cell carcinoma of the ovary with hypercalcemia: Report of a case of survival without recurrence 5 years after surgery and chemotherapy. Gyn Oncol, 1995, 56, p. 452–455.

10. Scully, RE. Small cell carcinoma of the hypercalcemic type. Int J Gynecol Pathol, 1993, 12, p. 148–152.

11. Ulbright ,TM., Roth, LM., Stehman, FB., et al. Poorly differentiated (small cell) carcinoma of the ovary in young women: evidence supporting a germ cell origin. Hum Pathol, 1987, 18, p. 175–184.

12. Wynn, D., Everett, GD., Boothby, RA. Small cell carinoma of the ovary with hypercalcemia causes severe pancreatitis and aleterd mental status. Gyn Oncol, 2004, p. 716–718.

13. Young, RH., Oliva, E., Scully, RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol, 1994, 18, p. 1102–1116.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 3

2015 Issue 3

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account