Hypersensitivity reactions to carboplatinand paclitaxel – our five-years experiences


Authors: A. Řezáč 1;  P. Jílek 2;  V. Řezáčová 3;  P. Škapinec 1;  I. Sedláková 1;  J. Tošner 1;  J. Špaček 1
Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Hradec Králové, přednosta doc. MUDr. J. Špaček, Ph. D., IFEPAG 1;  Katedra biologických a lékařských věd, Farmaceutická fakulta LF UK, Hradec Králové, vedoucí katedry doc. PharmDr. P. Nachtigal, Ph. D. 2;  Ústav klinické imunologie a alergologie FN, Hradec Králové, přednosta prof. RNDr. J. Krejsek, CSc. 3
Published in: Čes. Gynek.2013, 78, č. 6 s. 514-521
Category: Original Article

Overview

Objective:
To analyze hypersensitivity reactions to carboplatin and paclitaxel in patients treated with systemic administration of chemotherapy (carboplatin and/or paclitaxel).

Design:
Retrospective study.

Setting:
Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove.

Methods:
One hundred-forty patients treated with systemic administration of chemotherapy were enrolled to our study between years 2008 and 2012. The presence and the grade [grade (G) 1–5; 1 = moderate, 5 = death] of hypersensitivity reactions (HSRs) were evaluated, as well as the influence of some clinical parameters on development of HSR.

Results:
In total 29 HSRs in 21 patients were analyzed. To carboplatin were reported 19 (66%) HSRs: 13 (45%) HSRs of G1–G3 and 6 (21%) HSRs of G4. To paclitaxel were reported 10 (34%) HSRs: 9 (31%) HSRs of G1–G3 and 1 (3%) HSR of G4. The number of administered cycles of carboplatin to develop G1–G4 resp. G1–G3 HSR was higher in comparison with number of cycles to develop HSR of the same grade to paclitaxel(p = 0.001, resp. p = 0.01).

Conclusion:
HSR to carboplatin is unlike paclitaxel affected by the number of administered cycles. This fact should be included in the clinical management of patients treated with intravenous chemotherapy using carboplatin.

Keywords:
chemotherapy – allergic reaction – ovarian cancer


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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