Management of preterm prelabor rupture of membranes with respect to the inflammatory complications – our experiences


Authors: M. Kacerovský 1;  I. Musilová 1,2
Authors‘ workplace: Porodnická a gynekologická klinika LF UK a FN, Hradec Králové, přednosta doc. MUDr. J. Špaček, Ph. D., IFEPAG 1;  Porodnická a gynekologická klinika, Krajská nemocnice, Pardubice, přednosta doc. MUDr. M. Koštál, CSc. 2
Published in: Čes. Gynek.2013, 78, č. 6 s. 509-513
Category: Original Article

Overview

Objective:
Preterm prelabor rupture of membranes is responsible for approximately one third of all preterm deliveries. The most common complications associated with this pregnancy pathology are microbial invasion of the amniotic cavity, intraamniotic inflammation, intraamniotic infection and histological chorioamnionitis. This article explains these complicatinos and their relation to the optimal management of preterm prelabor rupture of membranes.

Design:
Overview study.

Setting:
Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove.

Methods:
To analyze current knowledge and our own experiences regarding inflammatory complications of preterm prelabor rupture of membranes.

Conclusion:
Inflammatory complications of preterm prelabor rupture of membranes are associated with risk of development of early onset sepsis. Nevertheless, gestational age is a main confounder affecting neonatal morbidity and mortality.

Keywords:
preterm delivery – intraamniotic inflammation – intraamniotic infection – chorioamnionitis


Sources

1. Blanc, WA. Pathways of fetal and early neonatal infection. Viral placentitis, bacterial and fungal chorioamnionitis. J Pediatr, 1961, 59, p. 473–496.

2. Buchanan, S., Crowther, C., Morris, J. Preterm prelabour rupture of the membranes: a survey of current practice. Aust N Z J Obstet Gynaecol, 2004, 44, p. 400–403.

3. Cobo, T., Kacerovsky, M., Palacio, M., et al. Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes. PLoS One, 2012, 7, e43677.

4. Cobo, T., Kacerovsky, M., Palacio, M., et al. A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. J Matern Fetal Neonatal Med, 2012, 25, p. 1995–2001.

5. Cobo, T., Tsiartas, P., Kacerovsky, M., et al. Maternal inflammatory response to microbial invasion of the amniotic cavity: analyses of multiple proteins in the maternal serum. Acta Obstet Gynecol Scand, 2013, 92, p. 61–68.

6. Gibbs, RS., Blanco, JD., St Clair, PJ., Castaneda, YS. Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis, 1982, 145, p. 1–8.

7. Kacerovsky, M., Andrys, C., Drahosova, M., et al. Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med, 2012, 25, p. 1699–1704.

8. Kacerovsky, M., Andrys, C., Hornychova, H., et al. Amniotic fluid soluble Toll-like receptor 4 in pregnancies complicated by preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med, 2012, 25, p. 1148–1155.

9. Kacerovsky, M., Celec, P., Vlkova, B., et al. Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria. PLoS One, 2013, 8, e60399.

10. Kacerovsky, M., Cobo, T., Hornychova, H., et al. Scavenger receptor for hemoglobin in preterm prelabor rupture of membranes pregnancies complicated by histological chorioamnionitis.J Matern Fetal Neonatal Med, 2012, 25, p. 2291–2297.

11. Kacerovsky, M., Musilova, I., Khatibi, A., et al. Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid proteins in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med, 2012, 25, p. 2014–2019.

12. Kacerovsky, M., Pliskova, L., Bolehovska, R., et al. The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM. Am J Obstet Gynecol, 2011, 205, p. 213, e1–7.

13. Kacerovsky, M., Pliskova, L., Bolehovska, R., et al. The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation. Am J Obstet Gynecol, 2012, 206, p. 342, e1–8.

14. Menon, R., Peltier, MR., Eckardt, J., Fortunato, SJ. Diversity in cytokine response to bacteria associated with preterm birth by fetal membranes. Am J Obstet Gynecol, 2009, 201, p. 306, e1–6.

15. Redline, RW., Faye-Petersen, O., Heller, D., et al. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol, 2003, 6, p. 435–448.

16. Salafia, CM., Weigl, C., Silberman, L. The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol, 1989, 73, p. 383–389.

17. Smith, G., Rafuse, C., Anand, N., et al. Prevalence, management, and outcomes of preterm prelabour rupture of the membranes of women in Canada. J Obstet Gynaecol Can, 2005, 27, p. 547–553.

18. Tsiartas, P., Kacerovsky, M., Musilova, I., et al. The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. J Matern Fetal Neonal Med, 2013, in press.

19. van der Ham, DP., Nijhuis, JG., Mol, BW., et al. Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial). BMC Pregnancy Childbirth, 2007, 7, p. 11.

20. van der Ham, DP., van der Heyden, JL., Opmeer, BC., et al. Management of late-preterm premature rupture of membranes: the PPROMEXIL-2 trial. Am J Obstet Gynecol, 2012, 207, p. 276, e1–10.

21. van der Ham, DP., Vijgen, SM., Nijhuis, JG., et al. Induction of labor versus expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks: a randomized controlled trial. PLoS Med 2012, 9, e1001208.

22. Yoon, BH., Jun, JK., Romero, R., et al. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol, 1997, 177, p. 19–26.

23. Yoon, BH., Romero, R., Park, JS., et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol, 2000, 182, p. 675–681.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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