The Age of Women Treated for Infertility Increases

Authors: A. Sobek ml. 1;  J. Vodička 1;  B. Hladíková 1;  E. Tkadlec 2;  A. Sobek 1
Authors‘ workplace: FERTIMED, Centrum pro léčbu neplodnosti, Olomouc 1;  Katedra ekologie a ŽP, Přírodovědecká fakulta, Univerzita Palackého, Olomouc 2
Published in: Čes. Gynek.2008, 73, č. 4 s. 227-230


The age of women at first child in the Czech Republic increases. We investigated whether this trend translates into the group of patients treated for infertility by IVF.

Fertimed, infertility centre, Olomouc.

We summoned data from 4689 women treated for infertility in our centre. We investigated the age of the patient, FSH levels, E2 levels, number of FSH units needed for ovarian stimulation, number of oocytes and embryos. We analysed the results by the method of regression analysis.

We found that the mean age increased from 28.7 to 32 years in a period of 10 years. We also demonstrated that the increasing age was accompanied by a decrease in ovarian function.

Women older than 32 years should be informed about the decreased ability to conceive. The treatment of women for infertility can be complicated by the growing age of patients in coming decades.

Key words:
infertility, age of a woman, ovarian function.


1. Asselt, KM., Kok, HS., Pearson, PL., et al. Heritability of menopausa age in mothers and daughters. Fertil Steril, 2004, 5, p. 1348-1351.

2. Augood, C., Duckitt, K., Templeton, A. Smoking and female infertility: a systematic review and meta-analysis. Hum Reprod, 2004, 13, p. 1532-1539.

3. Barnhart,K., Dunsmoor, R., Coutifaris, C. Effect of endometriosis on in vitro fertilization. Fertil Steril, 2002, 77, p. 328-336.

4. Burnham, KP., Anderson, DR. Model selection and multimodel inference: a practical information-theoretic approach. 2 ed. New York: Springer, 2002.

5. de Bruin, JP., Bovenhuis, H., van Nord, PAH., et al. The role of genetic factors in age at the natural menopause. Hum Reprod, 2001, 16, p. 2014-2018.

6. Den Tonklelaar, I., Te Velde, ER., Kolman, CW. Mentrual cycle lenght preceding menopause in relation to age at menopause. Maaturitas, 1998, 29, p. 115-123.

7. Faddy, MJ., Bossem, RG., Gougeon, A., et al. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod, 1992, 7, p. 1342-1346.

8. Fénichel, P., Sosset, C., Bernardino-Monnier, P., et al. Prevalence, specificity and significance of ovaria antibodies dutiny spontaneous premature ovaria failure. Hum Reprod, 2002, 12, p. 2623-2628.

9. Hoek, A., Schoemaker, J., Drexhage, HA. Premature ovaria failure and ovaria autoimmunity. Endocrine Rev, 2007, 18, p. 107-134.

10. Keay, SD., Liversedge, NH., Lenkins, JM. Could ovaria infection impaire ovaria response to gonadotrophin stimulation? Br J Gynaecol, 1998, 105, p. 252-254.

11. Lass, A., Ellenbogen, A., Croucher, C., et al. Efekt of salpingectomy on ovaria response to superovulation in an in vitro fertilization-embryotransfer program. Fertil Steril, 70, p. 1035-1038.

12. Naqvi, MM, Naseem, A. Obstetrical risks in the older primigravida, 2004, 14, 5, p. 278-281.

13. Sharara, F. ‚Poor responders‘ to gonadotrophins and levels of antibodies to Chlamyda trafomatis.. Fertil Steril, 1998, 1, p. 388-389.

14. Treolar, AE. Menstrual cyclicyty and the peromenopause. Maturita, 1981, 3, p. 49-64.

15. van Noord, PA., Dubas, JS., Borland, M., et al. Age at natural menopause in a population-based screening kohort: the role of menarche, fecundity and lifestyle factors. Fertil Steril, 1997, 68, p. 95-102.

16. Průměrný věk žen při porodu prvního dítěte v evropských zemích v letech 1960-2004,

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 4

2008 Issue 4

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account