Histopathological Prognostic Factors, Serum Markersand Selected Molecular Biological Factors in OvarianCancer

Authors: J. Špaček 1;  P. Jílek 2;  J. Petera 3;  Z. Tesařík 4
Authors‘ workplace: Klinika porodnictví a gynekologie, LF UK v Hradci Králové, přednosta doc. MUDr. J. Tošner, CSc. 2Katedra biologických a lékařských věd, FaF v Hradci Králové, přednosta doc. RNDr. V. Semecký, CSc. 3Klinika onkologie a radiologie, LF UK v Hradci Králové, př 1
Published in: Ceska Gynekol 2002; (6): 343-349


A review of histopathological prognostic factors, serum markers and selected molecularbiological factors in ovarian cancer.Design: Review.Setting: Department of Obstetrics and Gynaecology, Medical Faculty Hradec Králové, CharlesUniversity, Prague; Department of Biological and Medical sciences, Pharmaceutical Faculty, HradecKrálové, Charles University, Prague; Department of Clinical Oncology, Medical Faculty HradecKrálové, Charles University, Prague; Bristol-Myers Squibb, Department of Oncology, Prague.Method: Discussion about current evidence from literature.Conclusion: Except clinical prognostic factors the wide spectrum behaviour of epithelial ovariancancers is reflected by some histopathological prognostic factors, serum markers and some molecularbiological factors. The most important are grade and tumor ploidy, the level of CA 125 andits changes during the treatment, mutations of p53, BRCA 1 and 2.

Key words:
ovarian cancer, histopathological prognostic factor, grade, ploidy analysis

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