Resistance to Activated Protein C and Deep VenousThrombosis during Pregnancy
M. Procházka 1; V. Krčová 2; P. Hrachovec 1; M. Kudela 1; L. Slavík 2
Porodnicko-gynekologická klinika FN a LF UP Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 2Hematoonkologická klinika FN a LF UP Olomouc, přednosta prof. MUDr. K. Indrák, DrSc.
Čes. Gynek.2002, , č. 5 s. 251-254
The aim of the study was to detect the incidence of resistance to activated protein C inpregnant or puerperal women with confirmed diagnosis of deep venous thrombosis or pulmonaryembolism.Design: Case-control study.Setting: Dept. of Obstetrics and Gynaecology, Dept. of Haemato-oncology, Medical Faculty, PalackýUniversity, Olomouc.Methods: The group of 33 women with confirmed deep venous thrombosis were examined forresistance to activated C protein. The levels of C and S proteins, antithrombin III., prothrombin,heparin II cofactor and plasminogen were measured. Patient with APC ratio below 1.86, weretested by PCR analysis for the detection of the FV:Q506 allele.The control group had 51 pregnant women, chosen randomly. The statistical evaluation wasperformed by STATISTICA program. For the analyzing of the continuous variables the Students’T-test was used. For the categorical variables the 2 test was used (for comparison of 2 relativevalues). Values below P
thrombosis, pregnancy, thrombophilia
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Gynaecology and obstetrics