Resistance to Activated Protein C and Deep VenousThrombosis during Pregnancy


Authors: M. Procházka 1;  V. Krčová 2;  P. Hrachovec 1;  M. Kudela 1;  L. Slavík 2
Authors‘ workplace: Porodnicko-gynekologická klinika FN a LF UP Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 2Hematoonkologická klinika FN a LF UP Olomouc, přednosta prof. MUDr. K. Indrák, DrSc. 1
Published in: Čes. Gynek.2002, , č. 5 s. 251-254
Category:

Overview

Objective:
The aim of the study was to detect the incidence of resistance to activated protein C inpregnant or puerperal women with confirmed diagnosis of deep venous thrombosis or pulmonaryembolism.Design: Case-control study.Setting: Dept. of Obstetrics and Gynaecology, Dept. of Haemato-oncology, Medical Faculty, PalackýUniversity, Olomouc.Methods: The group of 33 women with confirmed deep venous thrombosis were examined forresistance to activated C protein. The levels of C and S proteins, antithrombin III., prothrombin,heparin II cofactor and plasminogen were measured. Patient with APC ratio below 1.86, weretested by PCR analysis for the detection of the FV:Q506 allele.The control group had 51 pregnant women, chosen randomly. The statistical evaluation wasperformed by STATISTICA program. For the analyzing of the continuous variables the Students’T-test was used. For the categorical variables the 2 test was used (for comparison of 2 relativevalues). Values below P

Key words:
thrombosis, pregnancy, thrombophilia

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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