Study of Local AnestheticsCLX. Determination of the Critical Micellar Concentration (c.m.c.) in Series of the Derivates Piperidinoethylesters of 3-Alkoxyphenylcarbamic Acid


Authors: F. Andriamainty;  J. Čižmárik;  Z. Mariščáková
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2002; , 154-156
Category:

Overview

We have determined the critical micellar concentration (c.m.c) of the derivates type piperidinoethyl esters 3-alkoxy phenylcarbamic in the medium 0.05 moUl and 0.2/moUl NaCI for using spectrophotometry methods in the UV region of the spectrum at temperature T=25 °C and pH=4.5-5.0. We found the parabolic dependence of the -ln(c.m.c.) on the (n) number of the carbon in the alkoxy substituent chain. Further, we have observed the facility formation of the micelle at the solution of 0.2 moUl than 0.05 moUl NaCI.

Key words:
piperidinoethyl esters 3-alkoxysubstituented of phenylcarbamic acid - critical micellar concentration (c.m.c.)

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Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy


2002 Issue 3

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