Studies of Local AnaestheticsCLIX. HPLC Separation of 1-Methyl-2-piperidinoethylesters of Alkoxyphenylcarbamic Acid

Authors: M. Renčová;  J. Čižmárik;  J. Lehotay;  K. Hroboňová
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava Katedra analytickej chémie Chemicko-technologickej fakulty STU, Bratislava
Published in: Čes. slov. Farm., 2002; , 150-153


The paper employed R- and y-cyclodextrins as chiral stationary phases in HPLC, the mobile phases being polar organic solvents. Enantiomers of alkoxysubstituted esters of phenylcarbamic acids (local anaesthetics) were separated and various effects on the process of separation were examined. Primarily the effects of the composition and concentration of organic solvents and the effect of the presence of ionic modifiers in the mobile phase were investigated. The conditions of separation of the enantiomers of phenylcarbamic acid derivatives were found. Interactions influencing separation of enantiomers are also discussed.

Key words:
separation of enantiomers - chiral staionary phases - HPLC - R-cyclodextrin - y-cyclodextrin - alkoxysubstituted esters of phenylcarbamic acid

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Pharmacy Clinical pharmacology

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Czech and Slovak Pharmacy

2002 Issue 3

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