Acute Encephalitis Caused by Influenza B Virus –  a Case Report

Authors: L. Petroušová 1;  L. Rožnovský 1;  J. Mrázek 2;  A. Kloudová 2
Authors‘ workplace: Klinika infekčního lékařství FN Ostrava 1;  Oddělení molekulární bio­logie, Zdravotní ústav se sídlem v Ostravě 2
Published in: Cesk Slov Neurol N 2013; 76/109(4): 515-517
Category: Case Report


Influenza-associated neurological complications are relatively rare, with potentially fatal haemorrhagic encephalitis being the most severe of them. Neurological complications are more common with infections caused by influenza A, influenza B-associated neurological complications are seen more frequently in paediatric patients. The case report describes severe encephalitis caused by influenza virus B in a 45-year-old man. The patient was quadruparetic during acute illness, required mechanical ventilation for 28 days, the recovery was prolonged, nevertheless the clinical condition normalized within seven months.

Key words:
influenza B –  encephalitis –  vaccination


1. Newland JG, Romero JR, Varman M, Drake C, Holst A,Safranek T et al. Encephalitis associated with influenza B virus infection in 2 children and review of the literature. Clin Infect Dis 2003; 36(7): e87– e95.

2. Morishima T, Togashi T, Yokota S, Okuno Y, Miyazaki C, Tashiro M et al. Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 2002; 35(5): 512– 517.

3. Kawada J, Kimura H, Ito Y, Hara S, Iriyama M, Yoshikawa T et al. Systemic cytokine responses in patients with influenza‑associated encephalopathy. J Infect Dis 2003; 188(5): 690– 698.

4. Akins PT, Belko J, Uyeki TM, Axelrod Y, Lee KK, Silverthorn J. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza. Neurocrit Care 2010; 13(3): 396– 406.

5. McCullers JA, Facchini S, Chesney PJ, Webster RG. Influeza B virus encephalitis. Clin Infect Dis 1999; 28(4): 898– 900.

6. Samuel N, Attias O, Tatour S, Brik R. Novel influenza A (H1N1) and acute encefalitis in a child. Isr Med Assoc J 2010; 12(7): 446– 447.

7. Wang CC, Chen PY, Wang JD, Liu FC, Huang FL, Lee CY. Clinical and laboratory analysis of influenza B infection in children in Taichung, Taiwan during the 2006– 2007 flu season. Pediatr Neonatol 2009; 50(2): 54– 58.

8. Straumanis JP, Tapia MD, King JC. Influenza B infection associated with encephalitis: treatment with oseltamivir. Pediatr Infect Dis J 2002; 21(2): 173– 175.

9. Džupová O, Havlíčková M, Helcl M, et al. Pacienti s pandemickou chřipkou A (H1N1) 2009 v intenzivní péči. Anest Intenziv Med 2010; 21(5): 251– 257.

10. FDA Authorizes Emergency Use of Intravenous Antiviral Peramivir for 2009 H1N1 Influenza for Certain Patients, Settings [on-line]. Available from URL: http:/ / newsevents/ newsroom/ pressannouncements/ ucm187813.htm.

11. Národní akční plán na zvýšení proočkovanosti proti sezónní chřipce v České republice [online]. Available from URL: http:/ / Verejne/ dokumenty/ narodni‑ akcni‑ plan‑ na‑ zvyseni‑  proockovanosti‑ proti‑ sezonni‑ chripce‑ v‑ ceské‑ republice_5511_2073_5.html.

Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

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2013 Issue 4

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