Vertebral compression fractures in pediatric patients with Crohn´s disease: case reports

Authors: Čagalová Alžbeta 1;  Čierna Iveta 1;  Tichá Ľubica 1;  Trepáč Martin 2;  Podracká Ľudmila 1
Authors‘ workplace: Detská klinika LF UK a Národný ústav detských chorôb, Bratislava 1;  Ortopedická klinika LF UK a Národný ústav detských chorôb, Bratislava 2
Published in: Clinical Osteology 2018; 23(3): 126-131


Alterations in bone metabolism are a common complication of inflammatory bowel disease. In pediatric patients, the changes present themselves as growth retardation, decrese in bones mass with changes of its microstructure. Pathological changes can be seen already at the time of diagnosis of primary disease. Pathogenesis of bone loss is multifactorial. Symptoms of skeletal involvement include severe bone pain, backache, kyphosis and fractures. In the article, we present two interesting case reports of adolescents with osteoporosis and vertebral compression fractures that have been manifested during Crohn’s disease.


body mass index – Crohn’s disease – vertebral compression fractures

  1. Greer FR, Krebs NF. [American Academy of Pediatrics Committee on Nutrition].Optimizing bone health and calcium intakes of infants, children, and adolescents. Pediatrics 2006; 117(2): 578–585. Dostupné z DOI: <http://doi 10.1542/peds.2005–2822>.
  2. Laakso S, Valta H, Verkasalo M et al. Compromised peak bone mass in patients with inflammatory bowel disease – a prospective study. J Pediatr 2014; 164(4): 1436–1443. Dostupné z DOI: <http://doi 10.1016/j.jpeds.2014.01.073>.
  3. Gilbert L, He X, Farmer P, et al. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 2000; 141(11): 3956–3964. Dostupné z DOI: <http://doi 10.1210/endo.141.11.7739>.
  4. Ward LM. Osteoporosis due to glucocorticoid use in children with chronic illness. Horm Res 2005; 64(5): 209–221. Dostupné z DOI: <http://doi 10.1159/000088976>.
  5. Hildebrand H, Karlberg J, Kristiansson B. Longitudinal growth in children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1994; 18(2): 165–173.
  6. Kappelman MD, Galako JA, Porter CQ et al. The Risk of Diagnosed Fractures in Children with Inflammatory Bowel Diseases. Inflamm Bowel Dis 2011; 17(5): 1125–1130. Dostupné z DOI: <http://doi 10.1002/ibd.21472>.
  7. Ahmed SF, Horrocks IA, Patterson T et al. Bone mineral assessment by dual energy X-ray absorptiometry in children with inflammatory bowel disease: evaluation by age or bone area. J Pediatr Gastroenterol Nutr 2004; 38(3): 276–280.
  8. Thearle M, Horlick M, Bilezikian JP et al. Osteoporosis: An anusual presentation of childhood Crohn’s disease. J Clin Endocrinol Metab 2000; 85(6): 2122–2126. Dostupné z DOI: <http://doi 10.1210/jcem.85.6.6640>.
  9. Patschan D, Loddenkemper K, Buttgereit F. Molecular mechanisms of glucocorticoid-induced osteoporosis. Bone 2001; 29(6): 498–505.
  10. Tichá Ľ, Payer J, Killinger Z et al. Kostný metabolizmus u pacientok s mentálnou anorexiou. Osteologický bulletín 2016; 21(2): 73–74.
  11. Wong SCh, Catto-Smith AGA, Zacharin M. Pathological fractures in paediatric patients with inflammatory bowel disease. Eur J Pediatr 2014; 173 (2): 141–151. Dostupné z DOI: <http://doi 10.1007/s00431–013–2174–5>.
  12. Payer J, Killinger Z. Osteoporóza. Herba: Bratislava 2012. ISBN 978–80–89171–94–1.
  13. Pappa H, Thayu M, Sylvester F et al. Skeletal health of children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2011; 53(1): 11–25. Dostupné z DOI: <http://doi 10.1097/MPG.0b013e31821988a3>.
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account