Type 2 diabetes mellitus and bone quality

Authors: MUDr. Raška Ivan, Ph.D.
Authors‘ workplace: III. interní klinika 1. LF UK a VFN v Praze
Published in: Clinical Osteology 2018; 23(3): 120-125

Diabetes mellitus 2. typu (DM2T) patří k častým onemocněním zejména u osob s nadváhou a obezitou. Diabetická neuropatie, retinopatie či nefropatie jsou dobře známé komplikace diabetu. V poslední době se dostávají do širšího povědomí také komplikace diabetu spojené s poruchou kostního metabolizmu. Bylo prokázáno, že pacienti s DM2T mají zvýšené riziko nízkozátěžových zlomenin včetně zlomenin kyčle.


Type 2 diabetes mellitus (T2DM) is a common disease occurring especially in overweight and obese patients. Dia­betic neuropathy, retinopathy or nephropathy are well known complications of diabetes. Recently, complications of diabetes associated with bone metabolism disorder are becoming more widespread. It has been shown that patients with T2DM have an increased risk of fragility fractures including hip fractures. Despite the increased risk of fracture, patients with T2DM have normal or even increased bone density. A bone quality disorder that we have not yet been able to evaluate non-invasively, plays an important role in the pathogenesis of increased bone fragility (dia­betic osteopathy). Further study is warranted to find another biochemical and imaging parameters that allow early recognition of patients with T2DM with an increased risk of fracture. Patients with T2DM with an increased risk of fracture should be actively sought and adequate preventive or therapeutic measures should be taken into account. The article gives a brief overview of the current knowledge and differences in bone metabolism in patients with T2DM and markers that appear to be promising indicators of bone quality disorder in patients with T2DM.


AGEs – osteoporosis – sclerostine – type 2 diabetes mellitus

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