Authors: I. Bouška 1; P. Klír 2 Authors‘ workplace: Ústav soudního lékařství UK 2. LF a FNB, Praha 2Subkatedra soudního lékařství IPVZ, Praha 1 Published in: Čes.-slov. Patol., , 2003, No. 1, p. 2-4 Category:
In the development of secondary changes of brain damage caused by injury, tumour and hypoxiaof different origin with unconsciousness also the activity of the metalloproteinase matrix (MMP)may participate. Their activation occurs first in the vascular wall which they damage and it maybe assumed that MMP potentiate thus secondary changes in the sense of interfering with thehaematoencephalic barrier with development of vasogenic cerebral oedema. In the cells of thevascular wall and in glial elements already after two days MMP-2 and MMP-9 activity was proved.While in focal injuries the findings were in particular at the site of contusion foci, in prolongedhypoxia for various reasons these changes were diffuse.
Key words: metalloproteinase matrix - cerebral hypoxia - secondary cerebral changes
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
