Catheter closure of PFO and paradoxical systemic embolisation

Authors: P. Kala;  M. Poloczek;  T. Brychta;  S. Nehyba;  V. Chaloupka
Authors‘ workplace: Interní kardiologická klinika FN Brno
Published in: Kardiol Rev Int Med 2010, 12(2): 84-87


Patent foramen ovale (PFO) is a common finding in the adult population. As it serves as a potential pathway for paradoxical systemic embolisation, it plays a pathophysiological role in various diseases. After exclusion of other known causes, catheter closure is a safe and effective procedure indicated most frequently in stroke patients, although it can also be used in secondary prevention of decompression illness, systemic embolisation into other organs etc. Therefore, the final diagnosis of cryptogennic stroke or TIA should be done only when the traditional risk factors, such as paradoxical embolisation in PFO, atrial septal defect or pulmonary shunts have been excluded. The results of multicentre randomized trials comparing pharmacological and catheterbased PFO treatment in stroke/TIA patients should be available during 2011.

patent foramen ovale – catheter closure – stroke – paradoxical embolisation


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