Last case of halothan hepatitis in the Czech Republic? Case report
Authors:
Ročeň Milan 1; Krak Martin 1; Fraňková Soňa 2; Kieslichová Eva 1; Trunečka Pavel 3
Authors‘ workplace:
Klinika anesteziologie, resuscitace a intenzivní péče IKEM
1; Klinika hepatogastroenterologie IKEM
2; Transplantcentrum IKEM
3
Published in:
Anest. intenziv. Med., 19, 2008, č. 4, s. 187-189
Category:
Anaesthesiology - Case Report
Overview
We describe a case of a 49 years old female patient with acute liver failure caused by halothan induced hepatitis. The liver failure was so severe that she was indicated for liver transplantation. The successful outcome of liver transplantation was facilitated also by supportive treatment with fractionated plasma separation and adsorption (FPSA) on Prometheus® device.
Key words:
halothan hepatitis – liver transplantation – Prometheus
Sources
1. Ray, D. C., Drummond, G. B. Halothane hepatitis. Br. J. Anaesth., 1991, 67, p. 84–89.
2. Kenna, J. G., Knight, T. L., van Pelt, FNAM. Immunity of halothane metabolite-modified proteins in halothane hepatitis. Ann. NY. Acad. Sci., 1993, 685, p. 646–661.
3. Bourdi, M. et al. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chemical Research in Toxicology, 1996, 7, p. 1159–1166.
4. Rifai, K. et al. Prometheus – new extracoporeal system for treatment of liver failure. J. Hepatol., 2003, 39, p. 984–990.
5. O’Grady, J. G., Alexander, G. J., Hayllar, K. M., Williams, R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology, 1989, 97, p. 439–445.
6. Kieslichová, E. et al. Úspěšná léčba akutního selhání jater pomocí přístrojové podpůrné terapie s následnou transplantací jater. Prakt. Lék., 2006, 86, No. 5, p. 275–277.
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2008 Issue 4
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