Postoperative Sedation with Dexmedetomidine in Patients after Off Pump Coronary ArteryBypass

Authors: V. Černý 1;  J. Samek 2,3;  D. Cichý 2
Authors‘ workplace: Riyadh2Klinika anesteziologie, resuscitace a intenzivní medicíny, Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové, Fakultní nemocnice Hradec Králové, přednosta doc. MUDr. Vladimír Černý, Ph. D., FCCM 3Kardiochirurgická klinika, Univerzita Ka 1
Published in: Anest. intenziv. Med., , 2004, č. 1, s. 21-27


Dexmedetomidinehas been shownas an effective agent for management of postoperative sedation and analgesiaon intensive care unit. The aim of the study was to assess dexmedetomidine for postoperative sedation in patients after OffPump Coronary Artery Bypass (OPCAB) surgery.Design: Prospective, non-randomized, cohort study.Setting: Dept. of Anesthesiology and Intensive Care, Charles University, Faculty of Medicine, University Hospital HradecKralove, Czech RepublicMaterial and methods: Study compares dexmedetomidine with standard analgesia protocol on cardiac surgical intensivecare unit. Twenty patients after OPCAB were included in the study, 10 patients were given standard analgesia protocol withpiritramid 15 mg I. M. q 12 hours (Group K), 10 patients were given dexmedetomidine (Group DEX) as loading infusion 1µg/kg for 10 minutes followed by maintenance infusion 0,2–0,7 µg/kg/hr up to 24 hours. Additional analgesia, if required,was provided by morphine 5 mg I. V. Age, sex, ASA, NYHA, Ramsay score (RS), blood pressure (BP), heart rate (HR),respiratory rate (RR), haemoglobin saturation (SaO2), length of ventilatory support (VS), length of ICU stay (LOS), dose ofdexmedetomidine and cost of analgesia and sedation were recorded. Statistical analysis was performed using SigmaStatStatistical Software, numerical data are presented as mean (range), *p

Key words:
postoperative – analgesia – sedation – cardiac surgery – OPCAB

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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