Prokalcitonin - the Sensitive and Specific Marker of Severe Bacterial Intlammation

Authors: Průcha Ml.;  R. Zazula;  J. Hyánek 2 1
Authors‘ workplace: lOddělení klinické biochemie, hematologie a imunologie, Nemocnice Na Homolce, přednosta prof. MUDr. Josef Hyánek, DrSc. 2Klinika anesteziologie, resuscitace a intenzívní péče, Institut klinické a experimentální medicíny, přednosta MUDr. Roman Zazula, PhD.
Published in: Anest. intenziv. Med., , 2002, č. 2, s. 83-85


The differential diagnosis of infectious and noninfectious ethiology of an injlammation is difficult problem in many clinical situations. In the nineties new important marker - procalcitonin - appears. Although its physiological role and regulation of its production is not sufficiently explained, procalcitonin has been shown to be important, sensitive and specific marker of the bacterial infection triggering a systemicinjlammatory reaction in the body. Nowadays procalcitonin is believed to be more specific marker of the severity of sepsis than interleukin-h or C-reactive protein. The determination of procalcitonin concentration is of important value for the diagnostic algorithm in critically ill patienxs and for antibiotic therapy.

Key words:
procalcitonin - sepsis - systemic injlammatory response syndrom - differential diagnosis

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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