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Premedikace moxonidinem (CYNT) a laparoskopická cholecystektomie
: J. Málek; M. Starec; M. Štefan; H. Vokounová
: Klinika anesteziologie a resuscitace 3. LF UK Praha, přednosta doc. MUDr. Jan Pachl, CSc. Ústav farmakologie 3. LF UK Praha, vedoucí prof. MUDr. M. Kršiak, DrSc.
: Anest. intenziv. Med., , 2001, č. 6, s. 288-290
:
Byl sledován vliv moxonidinu (CYNT) 0,3 mg (n = 22) a 0,4 mg (n = 25) p.o. na potlačení hemodynamických změn během laparoskopickécholecystektomie v porovnání s klonidinem (CATAPRESAN) 150 mg i.v. (n = 23) a kontrolou (n = 22). Moxonidin nebyl schopen na rozdíl od klonidinupotlačit vzestup krevního tlaku během kapnoperitonea, přestože u obou skupin s moxonidinem i ve skupině s klonidinem došlo k výrazně menšímuvýskytu hodnot tlaku nad 175/105 mmHg oproti kontrole (p < 0,001). Ostatní sledované parametry (spotřeba fentanylu, pooperační sedace, hypotenze,bradykardie, nauzea a zvracení) se mezi skupinami nelišily. Závěrem je možno shrnout, že použití kl onidinu v premedikaci před laparoskopickoucholecystektomií je výhodnější než použití moxonidinu.
Klíčová slova:
kapnoperitoneum – hypertenze – klonidin – moxonidin
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
Article was published inAnaesthesiology and Intensive Care Medicine
2001 Issue 6-
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