Moxonidine (Cynt) in Premedication and Laparoscopic Cholecystectomy

Authors: J. Málek;  M. Starec;  M. Štefan;  H. Vokounová
Authors‘ workplace: Klinika anesteziologie a resuscitace 3. LF UK Praha, přednosta doc. MUDr. Jan Pachl, CSc. Ústav farmakologie 3. LF UK Praha, vedoucí prof. MUDr. M. Kršiak, DrSc.
Published in: Anest. intenziv. Med., , 2001, č. 6, s. 288-290


We evaluated the effect of moxonidine (Cynt) 0,3 mg (n = 22) and 0,4 mg (n = 25) p.o. on the attenuation of haemodynamic response duringlaparoscopic cholecystectomy in comparison with clonidine (Catapresan) 150 mg i.v. (n = 23) and control group (n = 22). Compared to clonidine,moxonidine was not able to attenuate the rise in blood pressure during capnoperitoneum; however, both groups of moxonidine and clonidine shownless frequent occurrence of blood pressure readings over 175/105 compared to control group (p < 0.001). Other followed parameters (consumptionof fentanyl, postoperative sedation, hypotension, bradycardia, nausea and vomiting) did not differ among groups. In conclusion, administration ofclonidine in premedication before laparoscopic cholecystectomy provides better results, compared to moxonidine.

Key words:
capnoperitoneum – hypertension – clonidine – moxonidine

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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