Nitric oxide: its metabolism and importance for an organism

Authors: J. Racek;  I. Novák 1;  V. Holeček;  V. Šrámek 1
Authors‘ workplace: Ústav klinické biochemie a laboratorní diagnostiky1 I. interní klinika LF UK a Fakultní nemocnice v Plzni
Published in: Anest. intenziv. Med., , 1999, č. 4, s. 169-173


Nitric oxide is produced by various forms of nitric oxide synthases (NOS). Nitric oxide exerts various physiologic functions; NO producesvasodilation, inhibits thrombocytes aggregation, effects immune response and serves as a signal messenger. Nitric oxide with superoxide generatesperoxynitrite which destructs proteins by nitration. Nitric oxide can be applied in ARDS, septic shock, ischemic conditions, diabetes, inflammatoryconditions, rheumatoid arthritis and other clinical settings. It is used also in inhalational therapy.

Key words:
nitric oxide – nitric oxide synthase – ARDS – nitric oxide inhalation

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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