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Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19

14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent acute lung injury. Recently, it has been found that AAT also mitigates the course of COVID-19 disease by hindering the entry of the SARS-CoV-2 coronavirus into host cells. This dual antiviral and anti-inflammatory action makes AAT an excellent candidate for COVID-19 treatment.

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To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?

A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline…

14. 5. 2021 Source: Primary Biliary Cholangitis

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Treatment of Motor Symptoms of Parkinson's Disease

Parkinson's disease (PD) is one of the few neurodegenerative disorders for which effective symptomatic treatment is available. Unfortunately, causal or even neuroprotective therapy with proven…

12. 5. 2021 Source: Parkinson's Disease

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Liposomal Pegylated Irinotecan in the Treatment of Pancreatic Tumors

Combined treatment with liposomal pegylated irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) significantly improves overall survival in patients with metastatic ductal carcinoma of the…

11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas

New Treatment Option for Metastatic Pancreatic Cancer –⁠ Pegylated Liposomal Irinotecan

The 2019 review article is dedicated to the use of nanoliposomal irinotecan, its toxicity, and its potential use in the treatment sequence of metastatic pancreatic ductal adenocarcinoma.

11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas

What FVIII Levels Are Ideal for Preventing Bleeding in Hemophilia A?

Recent studies indicate that target trough levels of factor 1–3% during prophylactic treatment are insufficient to fully prevent clinical and subclinical bleeding. With a sustained FVIII level > 15%,...

10. 5. 2021 Source: Hemophilia

Can Co-administration of Dabigatran with Antiretroviral Drugs Be Effective and Safe?

In 2019, the first results regarding the concurrent use of antiretroviral drugs and oral anticoagulants were published. This involved 14 patients with atrial fibrillation and HIV infection, in whom…

6. 5. 2021 Source: Anticoagulant Treatment

Lékař v chirurgickém oděvu drží endoskop v ruce. Pacient a sestra v pozadí.

The Future and Prospects of Type 2 Diabetes Therapy: Can We Fully Cure It with Endoscopy or Genetics?

Diabetes mellitus (DM) cannot be cured, but it can be successfully treated... Will we rewrite this textbook fact passed down for years in the future? Will we be able to completely cure type 2…

6. 5. 2021 Source: Modern Treatment of Diabetes

Thyroid Function During COVID-19 Illness and After Recovery

Acute infection with the SARS-CoV-2 coronavirus has varying impacts on different organ systems of the human body. Until now, it has not been certain how precisely it affects the endocrine system,…

6. 5. 2021 Source: Thyroid Disorders

Increase in Thyroid Cancer Incidence Due to the Coronavirus Pandemic?

According to available data, COVID-19 disease does not worsen the course of thyroid cancer. However, the restriction of medical care during the pandemic is associated with concern about an increase…

6. 5. 2021 Source: Thyroid Disorders

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Sport and Physical Activity Benefit Hemophiliacs

Sport and physical activity are beneficial for individuals with hemophilia. This statement was confirmed by a study conducted by German and British authors published in the journal Haemophilia.

5. 5. 2021 Source: Hemophilia

Prenatal Phenotype of Children with Noonan Syndrome

Until recently, the various phenotypes of RASopathies were clinically diagnosed only after birth. However, we are now striving for the earliest possible diagnosis, sometimes even prenatally.…

4. 5. 2021 Source: Growth Disorders

Biological treatment of psoriatic arthritis in the 1st line –⁠ results of the SPIRIT-H2H study after 1 year of follow-up

The SPIRIT-H2H study compared the efficacy of ixekizumab and adalimumab, either as monotherapy or with concomitant methotrexate (MTX), in patients with psoriatic arthritis (PsA) who had not been…

3. 5. 2021 Source: Biological Treatment

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Perioperative Thromboprophylaxis in Elderly Patients

Thromboembolic disease (TED) is among the most common causes of death in hospitalized patients and also constitutes a significant portion of complications following surgical procedures. Without…

29. 4. 2021 Source: Thromboprophylaxis

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Extended Thromboprophylaxis with Enoxaparin After Bariatric Surgery

A recent retrospective study involving 312 patients after bariatric surgery indicated that extended thromboprophylaxis might be an appropriate approach for preventing postoperative venous…

29. 4. 2021 Source: Thromboprophylaxis

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