Itopride is a prokinetic used in the therapy of functional non-ulcerous upper dyspeptic difficulties. The mechanism of action involves inhibition of acetylcholinesterase and antagonism at dopamine D2 receptors. A clinical study by Belgian authors from the Catholic University of Leuven evaluated whether the effect of itopride is due to its influence on esophageal motility and lower esophageal sphincter function.
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