Search results: (10000)
News Current Treatment Options for Refractory/Relapsed CLL
How have treatment protocols for chronic lymphocytic leukemia changed in recent years? A review published in Acta Haematologica discusses the current therapeutic options for relapsed or refractory disease.
News Memantine Eases Daily Life for Patients and Caregivers
What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?
News Venotonics in Hemorrhoid Therapy – Results of a Systematic Review
Hemorrhoids are among the most common pathological findings in the anorectal area, and their incidence increases with age. Various modalities are used in the treatment of this condition, which has unpleasant health and psychological complications, aiming to alleviate the symptoms. Widely used and very popular are so-called venotonics, a large group of drugs and dietary supplements, mostly of natural origin, including diosmin.
News INFOGRAPHIC: LDL Cholesterol - Recommended Target Values
Elevated levels of LDL cholesterol are a significant risk factor for cardiovascular diseases, which remain the most common cause of death among adult Czechs. We have strong evidence about who and how LDL-c should be reduced, and ample treatment options to achieve this. Yet, more than half of the patients do not achieve the target LDL-c values. A useful tool for practice can be the 'risk traffic light' - an infographic clearly showing which risk category a patient falls into and what the recommended target LDL-c values are for each risk category. This makes it easier to plan tailor-made individual treatment.
News Dosing of Enoxaparin in Morbidly Obese Patients
How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.
News Benefit of a single intra-articular injection of hyaluronic acid in the treatment of osteoarthritis
Viscosupplementation serves as a minimally invasive procedure to restore the rheological properties of synovial fluid and alleviate pain in patients with symptomatic osteoarthritis (OA). We now have a new 3rd generation hyaluronic acid (HA) product for intra-articular injections – Hyruan One, which uses HA cross-linking technology. The following text summarizes its benefits in the pharmacological management of OA.
News Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy
Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the progression of osteoarthritis. An essential role in therapy is played by viscosupplementation in the form of intra-articular application of hyaluronic acid (HA). Currently, 3rd generation preparations intended for single application are preferred due to their efficiency and safety.
News Pregabalin in the Hands of a General Practitioner
A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy – conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?
News Etiology and Therapy of Dry Eye Syndrome in a Nutshell
Dry eye syndrome, the most common diagnosis in outpatient ophthalmology practice, is a multifactorial disease with varying severity of symptoms. It reduces the quality of life and can also affect the patient's visual functions. Therapy is individualized according to the primary trigger of the disease and aims to restore the homeostasis of the ocular surface and tear film. Due to the rapid pace of modernization associated with numerous extrinsic factors contributing to the development of dry eye syndrome, its incidence is rising, as well as the number of topical therapeutic options.
News What Next for Patients with CLL After Stopping Venetoclax?
Standard care for untreated patients with chronic lymphocytic leukemia (CLL) is therapy based on venetoclax. However, managing further treatment when venetoclax needs to be discontinued remains a relatively unexplored area without standardized protocols.
News Combination of Targeted Therapy with Chemo in 1st Line in Patients with Left-Sided wtRAS mCRC
The preferred targeted therapy added to the combination with standard chemotherapy (CHT) for left-sided metastatic colorectal cancer (mCRC) with non-mutated RAS oncogene should be an antibody against the epidermal growth factor receptor (anti-EGFR), not against the vascular endothelial growth factor (anti-VEGF). This is based on a direct comparison of anti-EGFR panitumumab and anti-VEGF bevacizumab in the Japanese phase III PARADIGM study. The results were presented at the ASCO 2022 annual meeting.
News How to Dose Beta-Blockers After Myocardial Infarction?
In patients after myocardial infarction (MI), there is a frequent administration of too low doses of beta-blockers (BB) and rare upward titration of their dose after discharge from the hospital. The SWEDEHEART study investigated to what extent the BB dose actually affects 5-year cardiovascular (CV) outcomes, and data from the American registry allowed a focus on mortality after MI depending on BB dosing.
News MD Šimon Kozák: In algology, nothing works miraculously overnight! It is important to seek advice from specialists
Why is it not advisable to rely on one method in pain treatment? What about patients with a mixed type of pain, whose numbers are increasing? And why shouldn’t surgical solutions for back pain be the method of first choice? We discuss all this and other important, current, and practical insights in the field of algology with the head of the pain treatment team at the Clinic of Anesthesiology and Resuscitation of the 3rd Faculty of Medicine, Charles University in Prague, and the University Hospital Královské Vinohrady, MD Šimon Kozák.
News Comparison of Efficacy of Bisoprolol and Metoprolol ZOK in Patients with Mild to Moderate Hypertension – Results of the CREATIVE Study
Suppression of increased activity in the sympathoadrenal system is currently one of the main goals of antihypertensive therapy. Beta-blockers play an important role in regulating the sympathetic nervous system. The CREATIVE study evaluated the efficacy of bisoprolol and metoprolol ZOK on blood pressure and heart rate in patients with mild to moderate primary arterial hypertension.
News Effectiveness of Bisoprolol in Patients with Cardiac Arrhythmias – A Systematic Review of Studies
Last year, a Franco-Romanian team published a study that conducted a systematic review of existing evidence on bisoprolol in the context of arrhythmia treatment. The authors noted that bisoprolol, like other beta-blockers (BB), is used for a variety of cardiovascular diseases, but it is not mentioned in the European Society of Cardiology (ESC) guidelines for managing patients with ventricular arrhythmias and preventing sudden cardiac death.