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News Metamizole, even after 100 years on the market, remains an important component of postoperative pain therapy

Metamizole has been used in the therapy of a wide range of acute and chronic pains for 100 years. Thanks to a number of advantages, it still represents one of the most frequently used analgesics in daily clinical practice.

Source: Analgesia 28. 2. 2022

News Proton radiotherapy means lower risk with high efficacy of radiation. The key is getting the patient into the treatment process as soon as possible

The Proton Therapy Center in Prague (PTC −⁠ Proton Therapy Center Czech) is a modern healthcare facility specializing in the treatment of oncological diseases using so-called proton radiotherapy. This therapy is covered by public health insurance in indicated cases. Since its opening in 2012, PTC has treated nearly 10,000 patients, not only from the Czech Republic and Slovakia. In 2019, it became part of the National Oncology Center.

Source: Proton Radiotherapy 8. 2. 2023

News Treatment of Cough in Clinical Practice: Which Preparations Are Suitable and When?

In clinical practice, we differentiate the treatment of non-productive and moist productive cough. When choosing appropriate therapy, we consider the characteristics of the available medicinal products, such as sedation, route of administration, potentiation of antibiotic effect, or anti-inflammatory effect. Combining antitussive and expectorant in one dose is irrational in any case. So, how should one proceed in the treatment of cough correctly?

Source: Cough Therapy 15. 2. 2022

News Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain

Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.

Source: Neuropathic Pain 21. 5. 2021

News Care of Surgical Wounds and Choice of Dressings −⁠ Main Findings of the Latest International Expert Consensus

In December 2022, Wounds International published a summary of consensus outputs from six international expert meetings dedicated to postoperative care of surgical wounds and the selection of their dressings.

Source: Wound Healing 19. 3. 2023

News Effect of Beta-Blockers on Glucose Metabolism and Their Use in Diabetics with Hypoglycemic Episodes

Beta-blockers, through their mechanism of action, can lead to the deepening or direct initiation of both hypoglycemia and hyperglycemia. The study presented below, published last year, evaluated the impact of beta-blocker treatment, their selectivity, and the predisposition of patients to hypoglycemia on the risk of mortality.

Source: Cardiovascular Continuum 21. 5. 2020

News Brain Metastases Are Not an Absolute Contraindication for Antiplatelet Therapy

On one hand, there's a higher risk of thromboembolic events, and on the other, a higher risk of intracranial bleeding. Prophylactic and therapeutic interventions for blood clotting are necessary for cancer patients in indicated cases. But what about the risk of bleeding in patients with CNS malignancies?

Source: Genetic Profile and Treatment of NSCLC 27. 12. 2021

Články časopisu Characteristics and results of treatment of younger patients less than 60 years old with AML: analysis of real data from the Czech DATOOL-AML database

Author of the article: L. Semerád, Z. Šustková, P. Cetkovský, P. Jindra, Z. Kořístek, J. Novák, T. Szotkowski, Z. Ráčil, J. Vydra, B. Weinbergerová, P. Žák, J. Mayer Source: Transfuze a hematologie dnes | 3/2020 17. 7. 2020

Články časopisu Prenatal growth curves of the Czech population

Author of the article: P. Polášková, A. Kuběna, P. Calda Source: Česká gynekologie | 4/2014 1. 8. 2014

News Thrombocytopenia Following mRNA Vaccination Against SARS-CoV-2

In connection with the administration of mRNA-based vaccines against the SARS-CoV-2 coronavirus, cases of secondary immune thrombocytopenia (ITP) have been described. A commentary published by a large team of authors in the American Journal of Hematology described a series of cases of low platelet counts identified within 2 weeks of vaccination. The data was obtained from the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), the Department of Health and Human Services (HHS), and the Vaccine Adverse Event Reporting System (VAERS), as well as through direct communication with patients and their physicians.

Source: Immune Thrombocytopenia 20. 5. 2021

Články časopisu Liver disease at alpha-1-antitrypsin deficiency

Author of the article: L. Husová, M. Dastych jr., E. Kunertová, P. Husa, K. Dvořák, M. Votava Source: Vnitřní lékařství | 1/2005 15. 1. 2005

News Benefit of Adding Erdosteine to Maintenance Treatment of COPD

Erdosteine is a mucoactive drug with anti-inflammatory, antioxidant, and anti-adhesive effects against bacteria, commonly used in the treatment of chronic obstructive pulmonary disease (COPD). In August 2022, another post-hoc analysis of the RESTORE study was published, evaluating the impact of its addition to COPD maintenance treatment on the incidence and severity of exacerbations and quality of life in patients with GOLD2 and GOLD3 grade bronchial obstruction.

Source: Cough Therapy 1. 11. 2022

News Long-term survival of a 50-year-old man with metastatic pancreatic cancer on a combination of nal-IRI + 5-FU/LV in 2nd line treatment −⁠ case study

A recently published case study from the Czech Republic describes a patient with progression of pancreatic cancer following surgical treatment and adjuvant chemotherapy, who achieved a one-year survival with good quality of life on a combination of nal-IRI + 5-FU/LV after the failure of gemcitabine + nab-paclitaxel in the 1st line of palliative treatment.

Source: Treatment of Gastrointestinal Carcinomas 3. 6. 2024

News Stabilization of Liver Metastases of CRC with Trifluridine/Tipiracil in 3rd Line Therapy –⁠ Case Study

We present a case study of a man born in 1944 who underwent resection of the rectosigmoid for multiple adenocarcinomas in February 2016. Subsequently discovered liver metastases were managed with several lines of palliative therapy in combination with repeated surgical resections. Trifluridine/tipiracil administered in the 3rd line represents a well-tolerated oral treatment for this patient, on which he achieved disease stabilization.

Source: Treatment of Gastrointestinal Carcinomas 10. 1. 2022

News Experience with Proton Radiotherapy for Anal Canal Carcinoma in Real Czech Practice

Radiotherapy has the potential to achieve complete tumor regression in patients with anal carcinoma, representing an effective alternative to radical surgery. However, it is associated with significant acute and late toxicity. Proton radiotherapy has shown better dose distribution in dosimetric studies compared to conventional photon therapy. What are the experiences with this treatment modality in real practice?

Source: Proton Radiotherapy 16. 10. 2023