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News Effect of Nuclear Magnetic Resonance Therapy in Patients with Osteoarthritis
Osteoarthritis represents the most common joint disease in adults, with its incidence and prevalence increasing with age. With the overall aging of the population, it is becoming a significant medical as well as social problem. Due to the growing number of cases, new modalities are being sought for current therapeutic procedures, including nuclear magnetic resonance therapy, whose effect has been verified by an extensive clinical study.
News Noonan's Syndrome – History and Present
The genetically determined syndrome linking congenital heart defect with a typical facial phenotype is named after Jacqueline Noonan, a pediatric cardiologist who practiced in the second half of the 20th century. She was the first to recognize and describe it. In the following text, we will briefly introduce it and discuss the circumstances of its discovery.
News Change in Release of Medication Pradaxa
Dear Doctor,
We would like to inform you that from April 1, 2021, based on the decision of the State Institute for Drug Control (SÚKL), the release of the medication (LP) Pradaxa (dabigatran-etexilate) 150 and 110 mg in the indication “Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation” will be changed to first-line treatment.
We would like to inform you that from April 1, 2021, based on the decision of the State Institute for Drug Control (SÚKL), the release of the medication (LP) Pradaxa (dabigatran-etexilate) 150 and 110 mg in the indication “Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation” will be changed to first-line treatment.
News FOLFOXIRI and Panitumumab in mCRC Treatment – Improvement in Treatment Response and Metastasis Resectability
For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin, irinotecan) regimens combined with monoclonal antibodies represent the standard first-line treatment. The FOLFOXIRI regimen, which is another option, was developed to further enhance the efficacy of chemotherapy. The German oncologists' VOLFI study investigated the effectiveness of combining targeted therapy and triplet chemotherapy compared to chemotherapy alone in previously untreated patients with mCRC without RAS oncogene mutation.
News Possible Uses of Desodrop in Therapy and Prevention of Ophthalmological Diseases
The medical device Desodrop is the first topical eye preparation based on ozone, intended for the prevention and therapy of eye infections and other diseases. Its efficacy and safety have been demonstrated through numerous experimental studies and clinical trials, making it a suitable alternative for topical therapy in children and adults.
News CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism
The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual variability in drug metabolism rates. Let’s take a closer look at one of the reasons why the same drug may work very well in one patient, not at all in another, and may cause serious side effects in a third.
News Prof. Martina Koziar Vašáková: In the spotlight of pulmonologists are now lung screening and chronic lung diseases
As part of a series of interviews with the heads of professional societies on the topic of hot topics 2023, we speak with the chairwoman of the Czech Pneumological and Phthiseological Society of the CLS JEP Prof. MUDr. Martina Koziar Vašáková, Ph.D.
News Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain
Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.
News Can We Lump All Gabapentinoids Together?
General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is gabapentinoids, specifically gabapentin and pregabalin. Are these substances completely interchangeable, or do their efficacy and practical application differ?
News Minimally Invasive Treatment of Pilonidal Sinus: Laser and Negative Pressure Therapy as a Gentle and Effective Modality
The increasing incidence of pilonidal sinus contributes to the development of new treatment methods. Experiences from AGEL Hospital Přerov show that the methods SiLaC (sinus laser ablation of the cyst) and NPWT (negative pressure wound therapy) represent a gentle and effective approach for pilonidal sinus, accelerating treatment and subsequent recovery.
News Prescription Restrictions on Antidiabetics Authorized for Prescription by General Practitioners - Status as of October 2020
Diabetes mellitus (DM) has become an increasing problem worldwide in recent years. Long-term complications of DM lead to increased morbidity and mortality in the diabetic population, and their prevention determines the main treatment goals of DM. The treatment and management of patients with type 2 diabetes (DM2) are provided by either a general practitioner's office (GP) or a diabetology clinic. According to available data, over 200,000 patients with DM2 are currently treated and managed in GP offices.
News Safety of Metamizole in Adult Patients – Meta-analysis of 79 Studies
Metamizole is a non-opioid analgesic with antipyretic and spasmolytic effects that has been used for over 100 years. It is approved for the treatment of children and adults in various dosage forms. German authors conducted a systematic literature review and meta-analysis of clinical studies to evaluate its safety compared to placebo and other analgesics in adult patients.
News Prevalence of Heart Failure and Its Subtypes in the Population of Developed Countries
In developed countries, heart failure occurs in approximately 2% of the population, with an annual incidence of 5-10/1000 inhabitants. The mortality rate for patients with chronic heart failure is 7.2% per year, and 31.9% of patients with heart failure are hospitalized annually. Portuguese authors attempted to assess the prevalence of heart failure and its subtypes in a population treated within one healthcare facility over 3 years.
News 48 Tablets of Teriflunomide? Nothing Should Be Overdone! − Case Study
A case study published in the Journal of Clinical Pharmacy and Therapeutics describes an overdose of teriflunomide, specifically the ingestion of 672 mg of this drug. What measures did the doctors take with the patient? And were they able to prevent serious consequences?
News Bimekizumab in the Treatment of Psoriatic Arthritis
Arthritis can appear in up to a third of patients with psoriasis, mostly after the onset of skin symptoms. Early recognition of this transition by dermatologists and general practitioners is crucial, as early intervention can prevent irreversible joint damage. In the context of effective biological therapy, there is even talk of the potential prevention of arthritis development in individuals with psoriasis.