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News Depakine Chrono versus Other Valproates in the Treatment of Bipolar Disorder

Bipolar disorder is among the most severe psychiatric illnesses, and if not treated properly, it can negatively affect the patient's quality of life. Does switching therapy from other valproates to Depakine Chrono lead to better outcomes in treating this disease? The following study aimed to find the answer to this question.

Source: Bipolar Disorder 18. 11. 2020

News Metformin with Extended Release in the Treatment of Prediabetes

The benefit of metformin in preventing the development of diabetes in people with prediabetes has been demonstrated in clinical studies. However, these studies evaluated immediate-release metformin, not its extended-release form (XR). Therefore, the results of an observational study conducted at Polish and Hungarian centers, which examined the efficacy and safety of metformin XR in patients with prediabetes, are important in this context. It is also necessary to add that in our country, no drug containing this active substance has yet received an approved indication for the therapy of patients with prediabetes.

Source: Modern Treatment of Diabetes 2. 11. 2022

Články časopisu Asthma bronchiale in the context of internal medicine

Author of the article: Milan Teřl Source: Vnitřní lékařství | 11/2017 2. 1. 2018

News Effect of Itopride on Esophageal Motility and Lower Esophageal Sphincter Function

Itopride is a prokinetic used in the therapy of functional non-ulcerous upper dyspeptic difficulties. The mechanism of action involves inhibition of acetylcholinesterase and antagonism at dopamine D2 receptors. A clinical study by Belgian authors from the Catholic University of Leuven evaluated whether the effect of itopride is due to its influence on esophageal motility and lower esophageal sphincter function.

Source: Gastrointestinal Treatment 21. 4. 2020

News Echocardiography in the Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?

Source: Amyloidosis 17. 4. 2023

News When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?

Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.

Source: Rare Diseases in Neurology 2. 5. 2023

News Non-Invasive Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis has always been considered a rare pathology. However, thanks to advancements in imaging methods and laboratory tests, it is now evident that it might be responsible for a larger amount of cardiac diseases than previously thought. Which non-invasive diagnostic methods are useful in identifying cardiac amyloidosis?

Source: Amyloidosis 16. 1. 2023

News News in Laboratory Diagnostics of Early Sepsis −⁠ First Czech Experiences

Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The aim of the study by the Czech authors was to evaluate the diagnostic yield of new laboratory markers in the form of monocyte distribution width and specific markers on the surface of neutrophil granulocytes.

Source: Because 29. 11. 2021

News How to recognize amyloidosis as a cause of heart failure?

Although the fate of patients with heart failure has improved in recent decades, it remains a disease with a poor prognosis that significantly worsens the quality of life. The prevalence of heart failure is 1-2% in the adult population, but it increases with age and is more than 10% in people over 70. In addition to well-known causes, some rare nosological units, such as amyloidosis, can also be behind the development of heart failure.

Source: Amyloidosis 24. 2. 2022

News Updated Recommendations for Treatment of von Willebrand Disease

In 2021, new recommendations for the therapy of von Willebrand disease (vWD) were published, based on a consensus by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF), and the World Federation of Hemophilia (WFH). The recommendations comprise a total of 12 points and address not only prophylaxis but also gynecological and obstetric issues, for example.

Source: Von Willebrand Disease 28. 4. 2022

Články časopisu Cholangiocarcinoma: a pathologist’s point of view

Author of the article: J. Hrudka, E. Sticová Source: Rozhledy v chirurgii | 10/2022 8. 11. 2022

News Dust Mite Allergies: Common Does Not Mean Trivial

Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.' However, patients do not see it this way, so we should not lose sight of it.

Source: Dust Mite Allergy 22. 7. 2021

Články časopisu Ovarian epithelial malignant tumors in adolescence

Author of the article: Luboš Minář, Z. Ivanová, E. Jandáková Source: Česká gynekologie | 2/2014 21. 4. 2014

Články časopisu A new definition of status epilepticus and its pharmacological management

Author of the article: O. Strýček, V. Šrámek Source: Anesteziologie a intenzivní medicína | 4/2018 24. 9. 2018

News Long-Term Effect of Nuclear Magnetic Resonance Therapy on Osteoarthritis –⁠ An Unconventional Case Report

Osteoarthritis is among the most common health issues in adults, with its prevalence increasing with advancing age. There is currently no causal therapy for the disease; hence, the standard approach is symptomatic treatment with surgical joint reconstruction in advanced stages of the disease. The presented case report describes a successful case of long-term therapy for osteoarthritis using molecular biophysical stimulation.

Source: Treatment of the Musculoskeletal System 21. 2. 2020