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News How Does Memantine Currently Stand in Alzheimer's Disease and Other Dementias

A comprehensive meta-analysis from 2019 examined the effect and safety of administering memantine, particularly in patients with moderate to severe Alzheimer's disease. How did memantine fare?

Source: Cognitive in the treatment of Alzheimer's disease 17. 10. 2021

Články časopisu Perindopril and cardiovascular disease –⁠ 25 years of success in cardiology

Author of the article: J. Vítovec, J. Špinar, L. Špinarová Source: Kardiologická revue – Interní medicína | 3/2018 20. 9. 2018

News Hemorrhoidal Disease –⁠ A Civilization Illness Responsible for Perianal Discomfort

According to estimates, almost every second Czech will experience at least one attack of hemorrhoidal disease. Symptomatic hemorrhoids are found in about 5% of the population. Prevalence depends to some extent on lifestyle and dietary habits.

Source: Venous Insufficiency 8. 4. 2021

News Venous Insufficiency of the Lower Extremities –⁠ A Diverse Range of Risks, Manifestations, and Complications

Although initially often asymptomatic, chronic venous insufficiency includes a variety of symptoms. Some of its manifestations can be irreversible, increasing the socio-economic burden that this disease, especially in its advanced stages, represents. German authors have summarized the latest findings on the epidemiology, risks, pathogenesis, manifestations, and complications of CVI in their review.

Source: Venous Insufficiency 20. 11. 2020

News Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients

As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both in the initial phase of treatment and in the maintenance phase after achieving remission.

Source: Modulation of S1P in the Treatment of Autoimmune Diseases 9. 5. 2023

News Comparison of Efficacy of Bisoprolol and Metoprolol ZOK in Patients with Mild to Moderate Hypertension –⁠ Results of the CREATIVE Study

Suppression of increased activity in the sympathoadrenal system is currently one of the main goals of antihypertensive therapy. Beta-blockers play an important role in regulating the sympathetic nervous system. The CREATIVE study evaluated the efficacy of bisoprolol and metoprolol ZOK on blood pressure and heart rate in patients with mild to moderate primary arterial hypertension.

Source: Cardiovascular Continuum 17. 9. 2020

News Idiopathic Pulmonary Fibrosis from the Perspective of an Outpatient Pulmonologist

Idiopathic pulmonary fibrosis represents a rare disease of lung tissue with an as-yet-unexplained etiology. In the framework of differential diagnosis, it is necessary to consider the disease, as early diagnosis combined with the deployment of antifibrotic therapy extends patients' lives.

Source: Pulmonary Fibrosis 16. 4. 2020

News Streptococcus pneumoniae Serotype 3 Continues to Be the Most Frequent Cause of Invasive Pneumococcal Diseases in the Czech Republic

After 2 years influenced by the COVID-19 pandemic, the number of cases of invasive pneumococcal diseases (IPD) has returned to pre-2020 levels. Serotype 3 remains the most frequent cause of IPD for the twelfth consecutive year.

Source: Regular Vaccination 26. 10. 2023

News Reduction of LDL Cholesterol in the Prevention of Cardiovascular Morbidity and Mortality –⁠ Results of a Large Meta-Analysis

Elevated LDL cholesterol (LDL-c) is one of the main causes of atherosclerosis. The meta-analysis presented below examined the effect of reducing its levels on the risk of cardiovascular (CV) morbidity and mortality.

Source: Chronic Heart Failure and Lipidology 11. 6. 2021

News Overview of Regimen Measures for House Dust Mite Allergy

House dust mite allergy is one of the significant causes of respiratory allergies in both children and adult patients. In addition to pharmacological treatment, the cornerstone of therapy also includes non-pharmacological approaches, whether through regimen measures or with the help of products designed to eliminate mites.

Source: Dust Mite Allergy 31. 1. 2023

Články časopisu A geriatric patient in dialysis care –⁠ experience from the Centre for post-acute care at the Motol hospital

Author of the article: M. Nováková Source: Geriatrie a Gerontologie | 1/2018 30. 3. 2018

News Pharmacotherapy of Hip Osteoarthritis with Unsaponifiable Soy and Avocado Oil –⁠ Insights from the ERADIAS Study

Unsaponifiable soy and avocado oil is indicated for the symptomatic therapy of hip and knee osteoarthritis. Research primarily focuses on the effectiveness of the drug in patients with knee osteoarthritis; there are significantly fewer studies focused on the hip area and their results are not consistent. For this reason, an extensive study was conducted by French authors evaluating the impact of the drug on the progression of hip osteoarthritis in several hundred patients over the medium term.

Source: Osteoarthritis Therapy 27. 2. 2020

Články časopisu Skin conditions in patients with inflammatory bowel diseases

Author of the article: K. Jůzlová, M. Krásová, J. Hercogová Source: Gastroenterologie a hepatologie | 1/2017 21. 2. 2017

News Effect of Azacitidine in the Treatment of Acute Myeloid Leukemia on Long-Term Patient Survival

The work cited below presents freshly updated results from the Quazar AML-001 study evaluating azacitidine (AZA) in the treatment of acute myeloid leukemia (AML), now with a median follow-up period of 55.5 months. Among other things, clinical and biological variables predictive of long-term survival, defined here as survival ≥ 3 years from randomization within the study, were examined.

Source: Acute Myeloid Leukemia 6. 6. 2023

News Current Legislative Changes Relating to Medical Devices –⁠ Overview Summary in a Nutshell

In 2022, several legislative changes were introduced in the area of medical devices (MD) for moist wound care. We are summarizing the news from three sectors, as presented by Mgr. Jan Zahálka at the Interdisciplinary Cooperation in the Treatment of Wounds and Skin Defects congress in 2022: prescribing MD by nurses, European Union Medical Device Regulation (MDR), and the issue of MD as potential hazardous waste.

Source: Wound Healing 21. 2. 2023