Search

News Can the Use of Statins Help Reduce the Risk of Dementia?

A meta-analysis published last year by Taiwanese experts evaluated the connection between the use of statins and the incidence of dementia. What conclusions did the authors reach?

Source: Cardiovascular Risks 23. 3. 2021

News Doc. Jitka Fricová: The biggest challenge remains the patient with unbearable chronic pain

Research findings are pushing the boundaries of optimal chronic pain treatment, including better prevention and reduced side effects of analgesics. Algological care is readily accessible in the Czech Republic, yet it faces limitations, such as the less manageable nature of unbearable pain, particularly neuropathic or oncologic. We briefly discuss the topic with the head physician of the Pain Treatment Center at the Department of Anesthesiology, Resuscitation, and Intensive Care Medicine, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Doc. MUDr. Jitka Fricová, Ph.D.

Source: Analgesia 29. 3. 2023

News Diagnosis and Management of Interstitial Lung Processes Associated with Rheumatoid Arthritis

Interstitial lung processes (ILD) are common yet insufficiently diagnosed complications of rheumatoid arthritis (RA), significantly increasing the morbidity and mortality of patients. ILD can occur at any stage of RA, presenting a diverse clinical picture. Usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) are the most common findings on high-resolution CT (HRCT). Some patients with RA-associated ILD may exhibit a progressive phenotype characterized by expanding fibrotic changes on HRCT, declining lung function, worsening respiratory symptoms, and early mortality. A recently published review summarizes strategies for screening, monitoring, and managing ILD in RA.

Source: Progressive Interstitial Pulmonary Processes 3. 1. 2024

Články časopisu Anaesthesia for minor surgery in the early postpartum period –⁠ Czech and Slovak prospective national surveys

Author of the article: P. Tourač, J. Bláha, P. Nosková, R. Klozová, D. Seidlová, M. Grochová, M. Kosinová, Jiří Jarkovský, H. Zelinková, D. Schwarz, M. Svoboda, S. Richterová, O. Smékalová, B. Zaoralová, Z. Mrozek, Z. Krupková, L. Večeřa, H. Ivanková, A. Magyarová, J. Šimonová, J. Firment Source: Anesteziologie a intenzivní medicína | 2/2019 13. 5. 2019

News Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs

In the context of the significant advancements in the field of immunotherapy and evidence of its efficacy in the treatment of chronic lymphocytic leukemia, it is pertinent to ask how this will influence therapeutic strategies in the context of first-line treatment and what the role of chemoimmunotherapy will be in the algorithms for CLL. At the 2019 NCCN Annual Congress, a panel of experts, led by Professors William G. Wierda from Texas MD Anderson Cancer Center and Jennifer R. Brown from Dana-Farber Cancer Institute, debated this topic.

Source: Chronic Lymphocytic Leukemia 22. 4. 2020

Články časopisu Prescription and dosage of RAAS inhibitors in patients with chronic heart failure in the FAR NHL registry

Author of the article: Monika Špinarová, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Karel Lábr, Ondřej Ludka, Jiří Jarkovský Source: Vnitřní lékařství | 1/2019 20. 2. 2019

News Teriflunomide under the microscope in studies and practice

Not always do the conclusions from clinical studies fully confirm in real clinical practice. Does this also apply to teriflunomide? Is its efficacy and safety consistent across age groups and individual studies?

Source: Multiple Sclerosis 3. 5. 2022

News Effect of Discontinuing Inhaled Corticosteroids in Patients with COPD in Real Clinical Practice

Inhaled corticosteroids are prescribed to patients with COPD to prevent disease exacerbation. However, in clinical practice, they are often overprescribed in non-indicated cases. A study conducted in real clinical conditions evaluated the effect of discontinuing inhaled corticosteroids compared to continuing triple therapy in patients with COPD.

Source: COPD 16. 4. 2021

News How Does Artificial Intelligence Help in Drug Development?

In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer the development of new drugs?

Source: 20. 3. 2024

News The main advantage of sartans is a very good safety profile. Now it is about increasing adherence in hypertensive patients

The rules for initiating hypertension treatment have been simplified. The trend is to achieve blood pressure control as early as possible, making it unnecessary to wait for a longer period for the effect of non-pharmacological measures. One of the 4 main classes of antihypertensives is AT1 receptor blockers for angiotensin II –⁠ sartans, which bring several advantages. These include a low incidence of side effects, a good antihypertensive effect, or the possibility of use in fixed combinations. We will take a closer look at the current position of sartans in the treatment of hypertension with Assoc. Prof. Ondřej Petrák, MD, PhD, from the Center for Research, Diagnosis, and Treatment of Hypertension at the 3rd Internal Clinic -⁠ Clinic of Endocrinology and Metabolism at the 1st Faculty of Medicine, Charles University in Prague, and General University Hospital in Prague.

Source: Sartans in the Treatment of Hypertension 28. 3. 2023

News Monocyte Distribution Width as a New Indicator of Sepsis in High-Risk Patients

Most septic patients are first encountered in the emergency department, where sepsis detection is often delayed, partly due to a lack of effective biomarkers. The study presented below evaluated the diagnostic accuracy of monocyte distribution width in peripheral blood alone and in combination with white blood cell count evaluation for early sepsis detection.

Source: Because 13. 9. 2021

News How Does Memantine Currently Stand in Alzheimer's Disease and Other Dementias

A comprehensive meta-analysis from 2019 examined the effect and safety of administering memantine, particularly in patients with moderate to severe Alzheimer's disease. How did memantine fare?

Source: Cognitive in the treatment of Alzheimer's disease 17. 10. 2021

Články časopisu Perindopril and cardiovascular disease –⁠ 25 years of success in cardiology

Author of the article: J. Vítovec, J. Špinar, L. Špinarová Source: Kardiologická revue – Interní medicína | 3/2018 20. 9. 2018

News Hemorrhoidal Disease –⁠ A Civilization Illness Responsible for Perianal Discomfort

According to estimates, almost every second Czech will experience at least one attack of hemorrhoidal disease. Symptomatic hemorrhoids are found in about 5% of the population. Prevalence depends to some extent on lifestyle and dietary habits.

Source: Venous Insufficiency 8. 4. 2021

News Venous Insufficiency of the Lower Extremities –⁠ A Diverse Range of Risks, Manifestations, and Complications

Although initially often asymptomatic, chronic venous insufficiency includes a variety of symptoms. Some of its manifestations can be irreversible, increasing the socio-economic burden that this disease, especially in its advanced stages, represents. German authors have summarized the latest findings on the epidemiology, risks, pathogenesis, manifestations, and complications of CVI in their review.

Source: Venous Insufficiency 20. 11. 2020