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News Current ASH Guidelines for Management of ITP 2019 − Recommendations for Newly Diagnosed ITP in Adults
The American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP) at the end of 2019, where a panel of experts attempted to define evidence-based recommendations for the management of these patients.
News Pharmacotherapy of Hip Osteoarthritis with Unsaponifiable Soy and Avocado Oil – Insights from the ERADIAS Study
Unsaponifiable soy and avocado oil is indicated for the symptomatic therapy of hip and knee osteoarthritis. Research primarily focuses on the effectiveness of the drug in patients with knee osteoarthritis; there are significantly fewer studies focused on the hip area and their results are not consistent. For this reason, an extensive study was conducted by French authors evaluating the impact of the drug on the progression of hip osteoarthritis in several hundred patients over the medium term.
News Chronic Thromboembolic Pulmonary Hypertension – Editorial
Belicová M. Chronic Thromboembolic Pulmonary Hypertension in a Regional Hospital. Vnitř Lék 2011; 57(2): 140–146.
News First Effective Pharmacotherapy Modality for Negative Symptoms in Schizophrenia
Negative symptoms of schizophrenia significantly limit the quality of life and overall functioning of the patient. However, there have been no suitable medications to effectively suppress these symptoms until now. This is expected to change with the introduction of cariprazine into the antipsychotic armamentarium, as suggested by promising results from an analysis published last year in the journal European Psychiatry.
News Ketogenic diet in MS patients as an aid to increase microbiota diversity and quantity
A recent study published in the journal Frontiers in Microbiology explores the role of gut microbiota in multiple sclerosis, specifically the changes in its quantity and the potential for influencing microbiota through a ketogenic diet.
News Transfer of Microbiome from Mother to Child: A Key but Fragile Process
How does the transfer of gut microbiota between mother and child occur? Is this transfer clinically significant, and what factors can disrupt it? These questions are addressed in a 2019 review article by Dutch microbiologists.
News European Survey on Prophylactic Treatment of Chemotherapy-Induced Nausea and Vomiting Suggests Gaps in Practice and Ways to Improve
Using recommended guidelines for antiemetic prophylaxis can prevent chemotherapy-induced nausea and vomiting (CINV). Nurses play a significant role in administering prophylactic treatment for CINV. Therefore, a survey was conducted in 16 European countries among middle medical personnel to evaluate the use of recommended antiemetic prophylaxis in oncology practice and the obstacles to its administration.
News Initiation of Sacubitril/Valsartan After Acute Decompensation of Chronic Heart Failure: The Sooner, the Better
The recently published analysis of data from the extended open-label follow-up of participants in the PIONEER-HF study clearly pointed out the difference in outcomes and prognosis of patients, which is led by the initiation of the combined drug during hospitalization compared to its initiation shortly after discharge.
News Comprehensive View on Care for Patients with Urostomy
Thanks to improvements in surgical techniques and shorter hospital stays, patients with a stoma are returning to their home environment and to the care of outpatient doctors sooner. Quality care in the postoperative period is a crucial element in the prevention of complications, support of healing, and education of ostomy patients. Doctors caring for these patients should approach them comprehensively, considering all their needs and aspects.
News Could candesartan counteract adverse intestinal changes induced by hypertension?
An experimental study published last year was the first to show that administration of candesartan may increase the tightness of epithelial junctions in the intestinal wall and positively affect the composition of the microflora. It expands the knowledge of recently described pathophysiological changes in the gut associated with hypertension.
News Effects of Telmisartan on Vascular Endothelial Functions, Inflammation Parameters, and Insulin Resistance in Patients with CHD and DM
Patients with coronary heart disease (CHD) and diabetes mellitus (DM) often have dysfunctional vascular endothelium, increased inflammatory markers, and insulin resistance. The study presented below investigated the effects of telmisartan on these parameters associated with disease progression and worse prognosis.
News Metabolic Effect of Telmisartan and Candesartan in Kidney Transplant Patients
Increasing cardiovascular risk from complex causes warrants a comprehensive intervention. A prospective randomized crossover study compared the effects of telmisartan and candesartan on lipid and glucose metabolism in kidney transplant patients.
News Assessment of Infection Risk in Patients with Multiple Sclerosis Treated with Various DMDs
Although the increased risk of infections with some disease-modifying drugs (DMDs) is known, we still lack sufficient real-world clinical data to evaluate and compare the risk levels of individual drugs. A Swedish study therefore provides information about these risks with glatiramer acetate, beta interferon, natalizumab, fingolimod, and rituximab in the treatment of multiple sclerosis (MS).
News Pharmacokinetics and Safety Profile of Bilastine in Patients Aged 6–11 Years – Findings from Post-hoc Analysis of Studies
The second-generation antihistamine bilastine is approved in Europe for the treatment of allergic rhinoconjunctivitis and urticaria in children over 6 years old. Post-hoc analyses of two clinical studies focused on its safety profile and pharmacokinetics in the pediatric population.