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News Is It Necessary to Discontinue Dupilumab in Patients with Atopic Dermatitis During the COVID-19 Pandemic?
Italian authors described their experiences with remote treatment of 200 atopic dermatitis (AD) patients using dupilumab during the COVID-19 pandemic outbreak in spring 2020. Observations from clinical practice, published data, and pathophysiological considerations do not suggest an increased risk of SARS-CoV-2 infection in AD patients receiving this biological treatment.
News Early Implementation of Highly Effective Therapy for Multiple Sclerosis
The ongoing debate about changing the approach to treating relapsing-remitting multiple sclerosis (RRMS) from an escalation strategy to the early implementation of highly effective therapy (HET) is based on the documented high inflammatory activity of the disease in its early stages and the concept of a therapeutic window for its suppression shortly after diagnosis. We bring you a summary of several recent pieces of information about the benefits and safety of HET as an initial treatment for RRMS.
News Pediatric Immune Thrombocytopenia Does Not Overlap with Adult ITP
Immune thrombocytopenia (ITP) is a highly heterogeneous disease characterized by various bleeding manifestations and different needs for treatment or likelihood of remission. The difference is accentuated in terms of the disease course between children and adult patients.
News Long-term effect of the triple combination of perindopril, indapamide, and amlodipine on left ventricular hypertrophy in hypertension
A recent open-label interventional study aimed to describe the long-term effect of a fixed triple combination of perindopril, indapamide, and amlodipine compared to a free combination of a RAAS inhibitor, diuretic, and calcium channel blocker on the reduction of left ventricular hypertrophy (LVH) in hypertensive outpatients.
News Venous Insufficiency of the Lower Extremities – A Diverse Range of Risks, Manifestations, and Complications
Although initially often asymptomatic, chronic venous insufficiency includes a variety of symptoms. Some of its manifestations can be irreversible, increasing the socio-economic burden that this disease, especially in its advanced stages, represents. German authors have summarized the latest findings on the epidemiology, risks, pathogenesis, manifestations, and complications of CVI in their review.
News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab
The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.
News Experience with Proton Radiotherapy for Anal Canal Carcinoma in Real Czech Practice
Radiotherapy has the potential to achieve complete tumor regression in patients with anal carcinoma, representing an effective alternative to radical surgery. However, it is associated with significant acute and late toxicity. Proton radiotherapy has shown better dose distribution in dosimetric studies compared to conventional photon therapy. What are the experiences with this treatment modality in real practice?
News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia
The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.
News Tapentadol Hydrochloride in Clinical Practice – To Whom, When, How, and Why?
Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in neuropathic pain. The following brief overview summarizes its mechanism of action and resulting benefits, reimbursement and prescription conditions, its place in the pain management algorithm, and examples of its application in clinical practice.
News Impact of Smoking on Postoperative Wound Healing
Modern surgery aims to shorten postoperative hospitalization by providing faster recovery from surgical consequences. Due to principles of asepsis and antisepsis, wound healing has significantly improved and the occurrence of infectious complications has decreased. However, smoking significantly prolongs recovery. We present new study results comparing wound healing in smokers and non-smokers.
News Impact of Thyroid Dysfunction on the Cardiovascular System in Elderly Patients
The incidence of thyroid disease increases with age. In the Czech Republic, up to 5% of the population suffers from hypothyroidism, and the prevalence of hyperthyroidism is estimated at 0.2-1%. The following text discusses the impact of these thyroid disorders on the cardiovascular (CV) system in elderly patients.
News Osteonecrosis of the Jaw Associated with Antiresorptive Pharmacotherapy in Oncological Patients
Antiresorptive pharmacotherapy in the form of bisphosphonates and denosumab is associated, according to current knowledge, with the risk of jaw osteonecrosis, especially following dental procedures such as tooth extractions. The aim of the newly published systematic review was therefore to evaluate the incidence of this complication following dental extractions in connection with the administration of antiresorptive medication and to identify risk factors for jaw osteonecrosis in oncological patients.
News End of Unnecessary Biopsies? Prostate Health Index (PHI) in Detecting Aggressive Carcinoma
The Prostate Health Index (PHI) combines the results of three blood-derived parameters: total PSA (tPSA), free PSA (fPSA), and [-2]proPSA (p2PSA) into a single numerical score: PHI = (p2PSA / fPSA × √tPSA). It is a marker used to differentiate patients indicated for prostate biopsy, enabling prediction of cancer aggressiveness and helping to choose the optimal course of action for a particular patient. Its benefit in distinguishing aggressive prostate cancer from indolent tumors or benign lesions was already proven in 2015.
News Current Approaches to COPD Therapy According to GOLD Recommendations and in the Conditions of Czech Practice
Chronic Obstructive Pulmonary Disease (COPD) represents a significant global cause of morbidity and mortality with a high prevalence that is expected to increase significantly in the coming years. Since it is a preventable and treatable disease, active therapy, which is globally guided by international recommendations based on the GOLD strategy, plays an important role. However, in the following article, we will also place these recommendations in the current context of care for these patients in the Czech Republic.
News Low-Molecular-Weight Heparins in Thromboprophylaxis After Major Orthopedic and Traumatological Procedures According to Current Recommendations
Patients after major orthopedic and traumatological procedures are at high risk of thromboembolic disease. This is especially true for people undergoing hip and knee replacement or patients with a proximal femur fracture and severe lower limb injury. The routine implementation of pharmacological thromboprophylaxis, such as low-molecular-weight heparins, is currently the gold standard in perioperative care in these cases.