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News Overall Survival and Tolerance of Olaparib in the OlympiAD Study – Results of Extended Follow-up
Olaparib provides women with metastatic breast cancer with a germline BRCA mutation, who have not been pre-treated with chemotherapy, not only with extended progression-free survival but also, according to the latest reports, longer overall survival. Its tolerability is good over the long term.
News Safety and efficacy of dabigatran and other NOACs compared with warfarin in patients with atrial fibrillation – results of a large long-term prospective study
Anticoagulant therapy is key in the prevention of strokes in patients with atrial fibrillation. Until the introduction of new oral anticoagulants (NOACs), warfarin was the first-choice drug for these patients, but unlike NOACs, it requires careful dose titration and effect monitoring. The safety and benefits of using various anticoagulants were examined in the study below.
News Perioperative Management in Patients with Atrial Fibrillation Treated with NOACs
The recommended procedures for perioperative management in patients using novel oral anticoagulants (NOACs) stem from the requirement to minimize treatment interruption before and after surgical procedures to reduce the risk of bleeding and thromboembolism. The safety of these regimens in patients with atrial fibrillation was examined in the prospective PAUSE study presented below.
News Impact of Sacubitril/Valsartan Treatment on Left Ventricular Reverse Remodeling
A meta-analysis evaluated the effect of sacubitril/valsartan on echocardiographic parameters (not only) in patients with HFrEF. The authors focused on both the presence and significance of changes, as well as the speed of their onset after the initiation of treatment.
News Obstacle Called Vasospasm: Which Solution Is Most Effective in Microsurgery and How to Pharmacologically Assist It?
Turkish authors in their study focused on the use of metamizole in addressing vasospasm in microsurgery. Using an animal model, they sought to answer the question of how this drug compares to lidocaine and papaverine.
News Cannabidiol as a way to reduce anxiety in patients with Parkinson's disease?
A recent study by Brazilian authors examined the effects of cannabidiol on tremors and anxiety in patients with Parkinson's disease. Could it represent a promising modality in this indication?
News Comparison of the Efficacy and Safety of Two Enoxaparin Dosing Regimens in Patients After Chest Surgery
Effective prevention of thromboembolic disease in patients undergoing chest surgery is one of the key therapeutic goals. However, the question remains as to what dose of low molecular weight heparin is optimal for these individuals. A multicenter clinical trial compared the efficacy of a fixed dose of enoxaparin to a weight-adjusted dose.
News Thromboprophylaxis in Cancer Patients − Results of Current Meta-Analysis
A recently published meta-analysis shows the benefits of thromboprophylaxis in cancer patients, with no increased risk of severe bleeding complications.
News When Size Matters or What Is Small Is Effective
The systemic effect of an orally administered drug can be expected, among other things, if it has suitable physicochemical properties. How can insufficient absorption or poor solubility be solved? We provide the answer below.
News Diosmin Succeeded in Preventing Ovarian Hyperstimulation Syndrome in Study
In a recently published study, diosmin was evaluated in women undergoing in vitro fertilization (IVF). Attention was focused on its effect in preventing and treating ovarian hyperstimulation syndrome (OHSS).
News Preserving Quality of Life for Patients During Palliative Treatment of Triple-Negative Breast Cancer
An analysis of the quality of life of patients treated with a combination of atezolizumab with nab-paclitaxel for metastatic triple-negative breast cancer was published in the Annals of Oncology journal.
News Quality of Life of Patients on Adjuvant Treatment for HER2-Positive Breast Cancer
The KATHERINE clinical trial demonstrated that adjuvant therapy with trastuzumab emtansine compared to trastuzumab significantly improves invasive disease-free survival in patients with HER2-positive early breast cancer and residual invasive disease after prior treatment. A post hoc analysis of this study was published in the journal Cancer, focusing on patient-reported outcomes related to quality of life during and after treatment.
News High Dose of Protein Affects Mortality in Critically Ill Patients if They Do Not Have Sepsis
The optimal composition of nutrition in terms of adequate energy and protein intake for critically ill patients is still a subject of professional discussion. The study cited below aimed to shed more light on this issue by evaluating how early intake of high amounts of proteins and excessive energy intake affects mortality in these patients.
News Multiparametric Magnetic Resonance in Predicting Progression of Low-Risk Prostate Cancer
A newly published study has demonstrated the utility of imaging using multiparametric magnetic resonance imaging (mpMRI) and its interpretation using PI-RADS version 2 (Prostate Imaging Reporting and Data System) in predicting unfavorable disease outcomes in patients with prostate cancer suitable for active surveillance.
News Magnetic Resonance Can Reduce the Need for Prostate Biopsies
As early as 2013, Czech experts demonstrated that in patients with elevated prostate-specific antigen (PSA) levels, imaging using a 3-Tesla magnetic resonance (3T MRI) can replace biopsy in many cases when detecting prostate cancer.