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News Previous Treatment of Osteoporosis May Affect the Efficacy of Romosozumab

A study conducted by a team of authors from several clinical sites in Japan shows that the type and duration of previous osteoporosis treatment just before starting romosozumab affects its therapeutic effect. Romosozumab, as an antibody targeting sclerostin, stimulates bone formation and suppresses bone resorption. The authors of the study investigated whether the efficacy of 12-month treatment with romosozumab depends on the duration of prior treatment with teriparatide, denosumab, or oral bisphosphonates.

Source: Osteoporosis – Trends in Sequential Therapy 9. 5. 2024

News INFOGRAPHIC: Mavacamten in the treatment of obstructive hypertrophic cardiomyopathy

Obstructive hypertrophic cardiomyopathy (HCM) is most commonly caused by disorders of cardiac muscle proteins. How does targeted treatment for this disease work? We bring a concise, graphically processed overview of the efficacy and mechanism of action of the first selective cardiac myosin inhibitor.

Source: Hypertrophic Cardiomyopathy (HCM) 17. 5. 2024

News Current Therapy Options for Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is a chronic progressive disease that exclusively affects adults, predominantly of middle and older age. Until recently, the disease was practically untreatable. However, this has changed with the discovery of antifibrotic drugs, which have significantly altered the prognosis for patients. Early diagnosis and initiation of therapy at a specialized center, of which there are several in the Czech Republic, are essential for success.

Source: Pulmonary Fibrosis 4. 6. 2020

News Recurring allergy symptoms after waking up? It could be due to dust mites

Allergens that are part of the feces and exoskeleton of dust mites, invisible members of human households, can cause milder symptoms like mucosal swelling, itching of the nose or throat, but also a stronger immune reaction, asthma, or severe allergic rhinitis. It is stated that 1−2% of the global population suffers from dust mite allergy, which corresponds to 65−130 million people. Why does it arise and what can be done in its prevention and treatment?

Source: Dust Mite Allergy 19. 1. 2022

News Induction vs. Escalation Treatment: Which Strategy to Choose in the Therapy of Multiple Sclerosis?

Opinions on the optimal therapy for multiple sclerosis (MS) are constantly evolving, and experts are debating the most appropriate first-line treatment strategy. A British cohort study focused on the long-term outcomes of induction and escalation therapies, two key approaches in the treatment of MS.

Source: Multiple Sclerosis 25. 6. 2020

News Wound Healing and Exudate –⁠ A Comprehensive Look at Moisture Management in Wounds

Exudate produced during the inflammatory phase of healing is a crucial factor that ensures a moist environment in the wound, provides nutrients for cellular metabolism, and supports autolytic debridement. Without proper exudate management and maintenance of optimal moisture in the wound, patients are exposed to a range of risks and complications in healing.

Source: Wound Healing 14. 12. 2023

News Adequate Compensation of a Hypertensive Patient According to Current ESC Guidelines –⁠ Case Study

A 65-year-old man, hypertensive, visits the general practitioner for a check-up. He reports recent shortness of breath during mild exertion (walking up stairs). Two months ago, he had acute sinusitis, for which he was prescribed antibiotics (penicillin V) by a specialist. He experiences hip pain and suffers from a runny nose in the spring (allergy?). He has been treated for hypertension for approximately 8 years.

Source: Sartans in the Treatment of Hypertension 29. 9. 2020

Články časopisu Treatment strategies for myelodysplastic syndrome in 2021

Author of the article: Petra Bělohlávková Source: Vnitřní lékařství | 3/2021 21. 6. 2021

News INFOGRAPHIC: Determining the Target Intraocular Pressure in Glaucoma Therapy

The goal of glaucoma treatment is to preserve the visual field and the quality of life of patients. Currently, the only approach to preserving the visual field of patients is to reduce intraocular pressure (IOP). Its target value should be determined for each patient with consideration of individual risk factors. The following comprehensive infographic shows which factors should be considered according to the current recommendations of the European Glaucoma Society (EGS).

Source: Treatment of Glaucoma 14. 7. 2023

News INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy –⁠ Current Guidelines

What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure for monitoring patients and their at-risk relatives? The comprehensive infographic summarizes the current recommendations of American professional societies.

Source: Hypertrophic Cardiomyopathy (HCM) 1. 11. 2023

News Combined Treatment of Chronic Lymphocytic Leukemia in Frail Patients –⁠ Results from Real-World Clinical Practice

Treatment of older patients and those with chronic lymphocytic leukemia (CLL) who are not in good physical condition has advanced significantly in recent years. The addition of obinutuzumab to chlorambucil therapy has extended both progression-free survival and overall survival for patients. The authors of the presented study evaluated the efficacy and safety of obinutuzumab in real-world clinical practice.

Source: Non-Hodgkin Lymphomas and CLL 11. 5. 2020

News Autonomic Dysfunction in Patients with Transthyretin Amyloidosis

Autonomic nervous system disorders are a common complication of transthyretin amyloidosis. Their frequency, nature, and impact on patients' quality of life were examined in the longitudinal THAOS study.

Source: Amyloidosis 12. 7. 2022

Články časopisu Importance of outpatient ultrasonografically guided transvaginal hydrolaparoscopy in the decision algorithm of care for the infertile couple.
The results of the Centre for Assisted Reproduction Gennet Liberec 2012–2013

Author of the article: V. Mokrá, I. Petr, J. Soukeník Source: Česká gynekologie | 3/2014 18. 6. 2014

News Comparison of Pharmacological Properties of Micronized Diosmin and Hesperidin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids

Diosmin and hesperidin belong to the group of bioflavonoids, which currently find wide application in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both flavonoids have been described to have a similar, but still not fully understood mechanism of action. Nevertheless, diosmin significantly differs from hesperidin, especially in pharmacokinetic parameters, which makes it the main carrier of the effect of venotonics.

Source: Venous Insufficiency 6. 10. 2020

News Efficacy of Dabigatran on Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation

The direct thrombin inhibitor dabigatran has shown interesting efficacy in a smaller clinical study in patients with atrial fibrillation and a thrombus in the left atrial appendage. Chinese authors evaluated the results of anticoagulant therapy using transthoracic and transesophageal echocardiography.

Source: Anticoagulant Treatment 22. 2. 2021